5-HT_(3)受体抑制剂预防成人术后恶心呕吐的研究进展

Research Progress of 5-HT_(3) Receptor Inhibitors in Preventing PONV in Adults

术后恶心呕吐(PONV)是常见的术后并发症之一。PONV增加了患者痛苦、医疗费用及术后风险。临床中多种因素可导致PONV的发生,如吸入性麻醉药、阿片类药物、腹腔镜所建立的气腹等,可通过5-HT_(3)受体等各种受体等介导恶心或呕吐的发生。因此阻滞5-HT_(3)受体神经传导通路是预防PNOV的重要方法。本文综述了5-HT_(3)受体抑制剂应用于预防成人PONV研究进展,为提高围手术期患者就医体验、缩短住院时间提供一定的参考。

Postoperative nausea and vomiting are one of the common postoperative complications. PONV increases patients’ pain, medical expenses and postoperative risks. Many factors in clinic lead to PONV, such as inhalation anesthetics, opioids, pneumoperitoneum established by laparoscopy and other stimuli, which can mediate the occurrence of nausea or vomiting through various receptors such as 5-HT_(3)receptor. Blocking 5-HT_(3)receptor nerve conduction pathway is an important method to prevent PNOV. This paper reviews the research progress of 5-HT_(3)receptor inhibitors in the prevention of PONV in adults, so as to provide some reference for improving the experience of patients in perioperative period and shortening the hospitalization time.