体外膈肌起搏器技术对支气管扩张症急性加重期患者的疗效分析

Analysis of the efficacy of external diaphragm pacing technique on clinical treatment of patients with acute exacerbation of bronchiectasis

目的评估体外膈肌起搏器(EDP)技术对支气管扩张症急性加重期患者临床治疗效果的影响,为患者提供更具针对性的肺康复手段。方法回顾性研究2019年1月至2022年3月在佳木斯大学附属第一医院呼吸与危重症医学科住院确诊的162例支气管扩张症急性加重期患者的临床资料。其中81例患者(A组)给予常规治疗,另81例患者(B组)给予常规治疗及EDP技术治疗,根据脑电双频指数评分对2组患者的疾病严重程度进行评估,划分为轻、中、重度,并比较疗效。观察比较2组患者治疗前后的白细胞计数、肺通气功能指标[第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)]及临床症状变化情况。结果B组患者总有效率明显高于A组,差异有统计学意义(P<0.05)。2组患者治疗后白细胞计数、FEV 1、PEF较治疗前均有改善,B组轻度患者治疗后白细胞计数较A组变化更明显,B组重度患者治疗后FEV 1、PEF较A组变化更明显,差异均有统计学意义(P<0.05)。B组中、重度患者治疗后白细胞计数变化程度及B组轻、中度患者治疗后FEV 1、PEF的变化程度与A组比较,差异均无统计学意义(P>0.05)。结论EDP技术对支气管扩张症急性加重期患者治疗效果明显,可在一定程度上起到辅助治疗的作用,其可改善急性加重期患者肺通气功能,缓解临床症状。

Objective To evaluate the efficacy of external diaphragm pacing(EDP)technique on clinical treatment of patients with acute exacerbation of bronchiectasis and to provide more targeted means of lung rehabilitation for patients.Methods A retrospective study was conducted on 162 patients with acute exacerbation of bronchiectasis diagnosed in the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Jiamusi University from January 2019 to March 2022.A total of 81 patients were treated with routine treatment(group A),and the other 81 patients were treated with routine and EDP technique(group B),the severity of the disease was divided into mild,moderate and severe in both groups according to bronchiectasis severity index scores,and the curative effect was compared.The changes of white blood cell count,pulmonary ventilation function[Forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF)]and clinical symptoms in each group before and after treatment were observed and compared.Results The total effective rate of the group B was significantly higher than that of the group A,the difference was statistically significant(P<0.05).The white blood cell count,FEV_(1),and PEF of each group were improved after treatment,the change of white blood cell count of mild patients in the group B was more obvious than that of the group A after treatment,and the changes of FEV_(1)and PEF of severe patients in the group B were more significantly higher severe patients than those of the group A,all the differences were statistically significant(P<0.05).There were no significant differences in the degrees of change in white blood cell count in moderate and severe patients,and the changes of FEV_(1)and PEF between mild and moderate patients in the group B and the group A after treatment(P>0.05).Conclusion EDP technique has therapeutic effect on patients with acute exacerbation of bronchiectasis and can play an auxiliary role to some extent.It can improve pulmonary ventilation function and relieve clinical symptoms in patients with acute exacerbation.