氟西汀联合帕罗西汀口服治疗双相抑郁症的效果及对甲状腺激素水平的影响

Effect of Fluoxetine combined with Paroxetine in the treatment of patients with bipolar depression and its influence on thyroid hormone level

目的探讨分析氟西汀联合帕罗西汀口服治疗双相抑郁症对甲状腺激素水平的影响。方法选取2021年1月至2022年1月泉州市第三医院收治的60例双相抑郁症患者作为研究对象,按照随机数字表法分为观察组与对照组,每组30例。其中,对照组给予单独氟西汀治疗,观察组予以氟西汀联合帕罗西汀口服治疗。比较两组患者治疗前后的甲状腺激素水平与治疗效果。结果治疗前,两组患者血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)比较,差异无统计学意义(P>0.05);治疗后,两组患者T3、T4及TSH水平均低于本组治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论双相抑郁症患者甲状腺激素水平存在异常表现,抗抑郁治疗后患者均得到缓解,同时患者的激素水平得到有效调节。

Objective To explore and analyze the effect of Fluoxetine combined with Paroxetine on thyroid hormone level in the treatment of bipolar depression.Methods A total of 60 patients with bipolar depression admitted to the Third Hospital of Quanzhou from January 2021 to January 2022 were selected as research objects,they were divided into observation group and control group by random number table method,with 30 patients in each group.The control group was treated with Fluoxetine,while the observation group was treated with Fluoxetine combined with Paroxetine orally.The thyroid hormone levels and therapeutic effects were compared between the two groups before and after treatment.Results Before treatment,there were no significant differences in serum triiodothyronine(T3),thyroxine(T4)and thyroid stimulating hormone(TSH)between two groups(P>0.05).After treatment,the levels of T3,T4 and TSH in the two groups were lower than those before treatment,and indexes of the observation group were even lower than those of the control group,with statistical significances(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The thyroid hormone level of patients with bipolar depression is abnormal,all patients are relieved after antidepressant treatment,and the hormone level of patients is effectively regulated.