Methyl CpG binding domain protein 2(MBD2)in inflammation

To the Editor:Methyl CpG binding domain protein 2(MBD2)belongs to the histone deacetylase family,which promotes multi-gene expression by inhibiting methylation and participates in the pathological process of various diseases.Apoptosis and inflammatory response are the main mechanisms leading to a variety of immune diseases.MBD2,as an important methylation protein reader,has in recent years been shown to be indispensable in the inflammatory response.This paper summarizes the current understanding of inflammatory MBD2 biology and provides additional direction for the study of inflammatory mechanisms by summarizing the current understanding of the regulatory mechanisms of MBD2 in inflammatory diseases and the inflammatory pathways that may regulate dysfunction.PubMed,Embase,and Wanfang Data were searched up to May 2022 with no language restriction for reports on MBD2 in inflammatory pathways,immune cell differentiation,and macrophage polarization,among others.