超重/肥胖因素对反复呼吸道感染患儿血清免疫球蛋白及IGF-1水平的影响及意义

Effect of overweight/obesity on serum immunoglobulin and IGF-1 levels in children with recurrent respiratory tract infection

目的探究超重/肥胖因素对反复呼吸道感染患儿血清免疫球蛋白及IGF-1水平的影响及其临床预防价值。方法将2019年1月至2021年6月在资阳市第一人民医院治疗的反复呼吸道感染的患儿126例纳入分析,对比不同年龄段的BMI标准水平,区分患儿的体型情况,随后分析超重/肥胖患儿、消瘦患儿及体型正常患儿的血清IGF-1、免疫球蛋白水平,探究体型因素、血清IGF-1及免疫球蛋白(IgG、IgA、IgM)表达与患儿反复呼吸道感染的关联。结果126例反复呼吸道感染的患儿平均年龄(5.24±2.09)岁,其中男性71例,女性55例;轻症79例,重症47例;对比不同年龄段的BMI标准水平,研究检出超重肥胖患儿39例,消瘦患儿16例,其余71例患儿体型为正常。不同病情状态患儿中均可见消瘦者IGF-1及IgG、IgA、IgM表达水平最低(P<0.05);相关分析发现,轻症患儿、重症患儿以及全部患儿中,IGF-1及IgG、IgA、IgM表达与患儿身高、体重以及BMI水平均表现出正相关关联(均有P<0.05)。结论IGF-1及IgG、IgA、IgM表达下降和患儿的反复呼吸道感染病情加重存在关联,尤其是消瘦患儿中表现明显;其原可能与IGF-1低表达、生长发育不佳相关联,IgG、IgA、IgM低表达和免疫水平不佳相关联;可以在高危体型、低生长发育水平和免疫状态患儿中积极预防反复呼吸道感染,尤其是重症型反复呼吸道感染的出现。

Objective To explore the effect of overweight/obesity on the levels of serum immunoglobulin and IGF-1 in children with recurrent respiratory tract infection and its clinical preventive value.Methods In the study,126 children with recurrent respiratory tract infection admitted to our hospital from January 2019 to June 2021 were included in the analysis,and the BMI standard levels of different age groups were compared to distinguish the children′s body types,and then compared with the overweight/obese patients.The information of serum IGF-1 and immunoglobulin levels in infants,obese patients and normal children were analyzed and discussed,and the factors of body type,the expression of serum IGF-1 and immunoglobulin(IgG,IgA,IgM)and the relationship between repeated respiratory tract infection in children were analyzed and discussed.The association between occurrence and disease in order to guide prevention and clinical work.Statistical analysis was performed using SPSS 19.0.Results The average age of 126 children with recurrent respiratory tract infection was(5.24±2.09)years old,including 71 male children and 55 female children,79 mild children and 47 severe children.According to the BMI standard level of age group,39 overweight and obese children were detected in this study,16 were thin children,and the remaining 71 children were normal.The expression levels of IGF-1 and IgG,IgA,and IgM were the lowest among the children with different disease states(P<0.05).The expression of-1,IgG,IgA,and IgM was positively correlated with the children′s height,weight and BMI(all P<0.05).Conclusion The decreased expression of IGF-1,IgG,IgA and IgM was associated with the aggravation of recurrent respiratory tract infection,especially in emaciated children.It may be associated with low expression of IGF-1 and poor growth and development,low expression of IgG,IgA and IgM and poor immune level.It can actively prevent recurrent respiratory tract infection,especially severe syndrome recurrent respiratory tract infection,in children with high-risk body type,low growth and development level and immune status.