极速脉搏波成像技术评估中年志愿者颈动脉弹性与心血管疾病风险的相关性研究

Correlational Study Between Carotid Elasticity and Cardiovascular Disease Risk in Middle-Aged Volunteers Assessed by Ultrafast Pulse Wave Technology

目的应用极速脉搏波技术评估中年志愿者颈动脉弹性,分析其与心血管疾病风险的关系。方法选取2020年1月至2021年11月我院招募的273例中年志愿者为研究对象,应用极速脉搏波技术测量颈动脉收缩起始脉搏波速度(PWV-BS)、收缩末期脉搏波速度(PWV-ES),采用China-PAR模型评估10年内发生动脉粥样硬化性心血管病危险度并分为低危组(n=214)和中危组(n=59)。结果低危组和中危组间IMT、PWV-BS、PWV-ES存在明显差异(P<0.05),使用Pearson相关性分析PWV-BS、PWV-ES与China-PAR模型评估的危险度显著相关(r=0.621、0.727,P均<0.001),IMT呈弱相关(r=0.405,P<0.001)。多元逐步回归分析结果提示低危组中与PWV-BS呈明显正相关的是舒张压、腰围、LDL-C、年龄、收缩压(P均<0.05),中危组中与PWV-BS呈明显正相关的是舒张压、腰围、ALT(P均<0.05);低危组中与PWV-ES呈明显正相关的是舒张压、LDL-C、收缩压、年龄(P均<0.05),呈明显负相关的是HDL-C(P<0.001),中危组中与PWV-ES呈明显正相关的是舒张压、BMI、GLU、ALT(P均<0.05)。结论颈动脉极速脉搏波速度与心血管病风险明显相关,可以协助临床筛查和管理需要进行干预的人群,从而控制动脉硬化的发展。

Objective To evaluate carotid artery elasticity in middle-aged volunteers by ultrafast pulse wave technology,and to analyze its relationship with cardiovascular disease risk.Methods A total of 273 middle-aged volunteers recruited by our hospital from January 2020 to November 2021 were selected as research objects.Ultrafast pulse wave technology was used to measure the carotid pulse wave velocity at the beginning of systole(PWV-BS)and the pulse wave velocity at the end of systole(PWV-ES).The 10-year risk of atherosclerotic cardiovascular diseaseand was assessed using the China-PAR model and divided into low-risk(n=214)and medium-risk(n=59)groups.Results There were significant differences in IMT,PWV-BS and PWV-ES between the two groups(P<0.05).Pearson correlation analysis showed that IMT,PWV-BS and PWV-ES were positively correlated with the risk assessed by China-PAR model,which PWV-BS and PWV-ES were significantly correlated(r=0.621,0.727,both P<0.001),IMT was weakly correlated(r=0.405,P<0.001).The results of multiple stepwise regression analysis indicated that diastolic blood pressure,waist circumference,LDL-C,age and systolic blood pressure were significantly positively correlated with PWV-BS in low-risk group(all P<0.05),while diastolic blood pressure,waist circumference and ALT were significantly positively correlated with PWV-BS in middle-risk group(all P<0.05).Diastolic blood pressure,LDL-C,systolic blood pressure and age were significantly positively correlated with PWV-ES in low-risk group(all P<0.05)and HDL-C was significantly negatively correlated with PWV-ES(P<0.001).Diastolic blood pressure,BMI,GLU and ALT were significantly positively correlated with PWV-ES in middle-risk group(all P<0.05).Conclusion Carotid ultrafast pulse wave velocity is significantly related to the risk of cardiovascular disease and can assist in clinical screening and management of populations requiring intervention to control the development of atherosclerosis.