血管内介入联合自体血回收机治疗颅内静脉窦血栓形成

Endovascular intervention combined with autologous blood recovery machine in the treatment of intracranial venous sinus thrombosis

目的分析血管内介入联合自体血回收机治疗颅内静脉窦血栓形成的血管再通率、疗效及安全性。方法回顾性分析2012—2021年厦门大学附属中山医院的52例确诊颅内静脉窦血栓形成经抗凝治疗无效或重症患者的临床资料,采用多种血管内介入治疗,分为单纯组25例和联合组27例。比较2组患者手术血管再痛率、颅内出血发生率、中重度贫血发生率及手术操作时间。结果联合组中重度贫血发生率明显低于单纯组(3.7%对24%,P<0.05),联合组术后完全再通率明显高于单纯组(85.1%对60.0%,P<0.05)。单纯组手术操作时间明显高于联合组,差异有统计学意义[158(145~195)min对125(110~160)min,P<0.05]。结论血管内介入治疗颅内静脉窦血栓形成效果良好,安全性高,联合自体血回收机完全再通率高,可缩短手术操作时间、减少贫血发生。

Objective To analyze the vascular recirculation rate,efficacy and safety of endovascular intervention combined with autologous blood recovery machine in the treatment of intracranial venous sinus thrombosis.Methods Totally 52 patients with intracranial venous sinus thrombosis who failed to respond to anticoagulant therapy or who had severe neurological deficits were treated with multiple endovascular interventional therapy from 2012 to 2021 in the Zhongshan Hospital Affiliated to Xiamen University,and were divided into the simple interventional group(25 cases)and combined interventional group(27 cases),combined interventional group used autologous blood recovery machine.The rate of vascular recirculation,complication rate of intracranial hemorrhage and moderate to severe anemia and operation time were compared between two groups.Results The incidence of moderate to severe anemia in the combined group was significantly lower than that in the simple group(3.7%vs 24%,P<0.05),and the total postoperative recanalization in the combined group was significantly higher than that in the simple group(85.1%vs 60.0%,P<0.05).The operation time of the simple group was significantly longer than that of the combined group,and the difference was statistically significant(158(145-195)min vs125(110-160)min,P<0.05).Conclusion Endovascular treatment for intracranial venous sinus thrombosis is a safe and effective method,combined with autologous blood recovery machine is high complete repeatability,and can shorten the operation time and reduce anemia complications.