炎症性肠病与肥胖关系的研究进展

Research progress on the relationship between inflammatory bowel disease and obesity

全球范围内,肥胖的流行率和炎症性肠病(IBD)的流行率都在增加,肥胖已经成为一个全球性的健康问题,与以往认为IBD患者通常营养不良和体质量不足的看法相反,肥胖IBD患者的比例正在上升。肥胖影响IBD患者的疾病发展和对治疗的反应,脂肪组织产生促炎脂肪因子也是一个备受关注的研究领域。肥胖在这一群体的流行以至于需要更好地了解其对IBD管理的影响。本文就IBD与肥胖的流行病学、发病机制及治疗展开综述。

Both the prevalence of obesity and the prevalence of inflammatory bowel disease(IBD)are increasing worldwide.Obesity has become a global health problem,and the proportion of obese IBD patients is increasing,contrary to the old belief that IBD patients are often malnourished and underweight.Obesity affects disease progression and response to treatment in patients with IBD,and the production of pro-inflammatory adipokines from adipose tissue is also an area of concern.Obesity is so prevalent in this population that its impact on the management of IBD needs to be better understood.This article reviews the epidemiology,pathogenesis and treatment of IBD and obesity.