香青兰提取物治疗溃疡性结肠炎的网络药理学分析

A network pharmacological analysis of Dracocephalum moldavica L.extract in the treatment of ulcerative colitis

目的:基于网络药理学探讨香青兰提取物治疗溃疡性结肠炎的作用机制。方法:利用数据库收集香青兰提取物和溃疡性结肠炎的靶基因,通过蛋白质互作网络(Protein-Protein Interaction Networks,PPI)网络分析以及中心网络拓扑筛选,对靶基因进行基因本体论(GO)功能富集分析、《京都基因与基因组百科全书》(KEGG)通路富集分析。结果:通过检索数据库共获得172个香青兰提取物活性成分治疗溃疡性结肠炎的潜在靶点,同时,利用PPI网络分析筛选出了关键治疗基因,并对蛋白质群进行了生物学功能注释,此外,KEGG通路富集分析表明香青兰提取物治疗溃疡性结肠炎时涉及消化、免疫系统反应和炎症反应的多条相关通路。结论:香青兰提取物中的活性成分具有多种生物学功能,可作用于多条炎症、免疫及癌症相关通路,具有多成分、多靶点协同作用的特点。

Objective:To investigate the mechanism of action of Dracocephalum moldavica L.extract in the treatment of ulcerative colitis based on network pharmacology.Methods:The database was used to collect the target genes of Dracocephalum moldavica L.and ulcerative colitis.GO functional enrichment analysis and KEGG pathway enrichment analysis were performed on target genes through protein-protein interaction(PPI)network analysis and central topology screening.Results:A total of 172 potential targets for the treatment of ulcerative colitis with the active ingredients of Dracocephalum moldavica L.were obtained by searching the database.Meanwhile,the key therapeutic genes were screened by PPI network analysis,and the biological functions of the protein groups were analyzed for annotation.In addition,KEGG pathway enrichment analysis indicated multiple relevant pathways involved in digestion,immune system response and inflammatory response when Dracocephalum moldavica L.extract treating ulcerative colitis.Conclusions:The active ingredients in Dracocephalum moldavica L.extract have a variety of biological functions,which could act on sorts of inflammation,immune and cancer-related pathways for its multi-component and multi-target synergy.