基于Logistic回归的艾滋病患者肝脏影响因素分析

Analysis of Influencing Factors of Liver in AIDS Patients Based on Logistic Regression

目的研究艾滋病患者肝脏的各项生理指标变化与HIV病毒的关系,从而探究HIV诱发艾滋病患者肝异常的途径。方法选取山西某传染病医院2011年10月-2020年11月共140例患者的临床检查指标,建立SPSS中的二元Logistic回归模型,以白蛋白、谷丙转氨酶、谷草转氨酶等16项肝脏相关的各项生理指标为自变量,以是否患有艾滋病为因变量,建立二元Logistic回归模型,检验模型的可靠性,并进一步筛选关系显著性较强的自变量进一步回归分析,得出艾滋病患者肝脏影响因素。结果肝功能白球比(A/G)、球蛋白(GLO)、总蛋白(TP)与HIV感染的相关性最显著,且A/G偏低比偏高影响更大,GLO偏高比偏低影响更大,TP偏高比偏低影响更大。结论HIV感染可以诱发患者体内GLO增多,A/G降低,TP升高,从而导致患者发生慢性肝炎、肝硬化的可能性增加。

Objective To study the relationship between the changes of liver physiological indexes and HIV in AIDS patients to explore the way of liver abnormalities induced by HIV.Methods The clinical examination indexes of 140 patients in an infectious disease hospital in Shanxi from October 2011 to November 2020 were selected,and the binary Logistic regression model in SPSS was established.Sixteen liver-related physiological indexes such as albumin,alanine aminotransferase and aspartate aminotransferase were used as independent variables,and AIDS was used as the dependent variable.The binary Logistic regression model was established to test the reliability of the model,and the independent variables with significant relationship were further screened for further regression analysis to obtain the liver influencing factors of AIDS patients.Results The white globule ratio(A/G),globulins(GLO),and total protein(TP)of liver function had the most significant correlation with HIV infection,while the effect of low A/G was greater than that of high,high GLO was greater than that of low,and high TP was greater than that of low.Conclusion HIV infection can induce the increase of GLO,decrease of A/G and increase of TP in patients,which leads to the increase of the possibility of chronic hepatitis and cirrhosis.