香叶醇抗肿瘤活性及其他生物学作用的研究进展

Research progress on antitumor activity and other biological effects of geraniol

香叶醇(Geraniol,GI)是一种从芳香植物的精油中分离出来的无环类异戊二烯单萜,目前已有多项实验结果表明GI具有多种生物学活性,如抗肿瘤、抗炎、抗氧化和抗菌等以及对肝脏、心脏和神经等保护作用。GI对不同类型肿瘤有治疗或预防作用。此外,GI还可通过调控多种肿瘤细胞的信号分子和通路从而增强肿瘤细胞对化疗药物的敏感性。因此,GI可以作为一种有前途的生物活性化合物来治疗或预防慢性疾病。本文对GI抗肿瘤以及其他生物学作用方面的研究进展情况进行综述。

Geraniol(GI)is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants.So far,a number of experimental evidence has demonstrated that GI has various activities,such as anti-tumor,anti-inflammatory,antioxidant and antibacterial activities,as well as liver protection,heart protection and neuroprotection.GI has therapeutic or preventive effects on different types of tumor,and the mechanism basis of its pharmacological action has been revealed.In addition,GI enhances the sensitivity of tumor cells to commonly used chemotherapy drugs.GI controls a variety of signaling molecules and pathways that represent tumor characteristics.These effects of GI limit the ability of tumor cells to acquire adaptive resistance to antitumor drugs.Thus,the above studies indicate that GI can be used as a promising bioactive compound to treat or prevent chronicle diseases.This article reviews the research progress of GI in anti-tumor and other biological effects.