铁死亡在泌尿系统肿瘤中的作用及其机制研究进展

Research progress on the role and mechanism of ferroptosis in urinary neoplasms

铁死亡是近年来新发现的一种不同于凋亡、坏死和自噬的程序性细胞死亡。细胞内谷胱甘肽及谷胱甘肽过氧化物酶抗氧化防御系统调控异常及铁离子依赖性膜结构脂质过氧化的蓄积是铁死亡发生的主要病理生理改变。铁死亡参与包括肿瘤、缺血再灌注损伤及神经系统疾病等多种疾病的发生发展过程。近年来研究发现铁死亡与泌尿系统肿瘤密切相关,本文概述了铁死亡在泌尿系统肿瘤发生及进展中作用的相关调控分子机制,旨在为泌尿系统肿瘤的临床治疗提供新的方向。

Ferroptosis is a newly discovered programmed cell death in recent years,which is different from apoptosis,necrosis and autophagy.Abnormal regulation of intracellular glutathione or glutathione peroxidase antioxidant defense system and accumulation of iron iron-dependent membrane structure lipid peroxidation are the main pathophysiological changes of ferroptosis.Ferroptosis is involved in the occurrence and development of various diseases including tumors,ischemia-reperfusion injuries and neurological diseases.In recent years,studies have found that ferroptosis is closely related to urinary system tumors.This paper summarizes the relevant regulatory molecular mechanisms of ferroptosis in the occurrence and progression of urinary system tumors,aiming to provide a new direction for the clinical treatment of urinary system tumors.