阿戈美拉汀+认知行为疗法联合针刺治疗失眠症的效果对比研究

Comparative Study of Agomelatine+Cognitive Behavioral Therapy Combined with Acupuncture in the Treatment of Insomnia

目的:探讨失眠症患者采用阿戈美拉汀+认知行为疗法联合针刺治疗的效果。方法:选择2021年8月-2022年2月赣州市第三人民医院收治的失眠症患者68例,根据随机数字表法将其分为两组,各34例。对照组采用阿戈美拉汀+认知行为疗法治疗,观察组采用阿戈美拉汀+认知行为疗法与针刺联合治疗,两组均连续治疗12周。评估两组治疗效果,于治疗前、治疗2、4、8、12周评估两组焦虑抑郁状况及睡眠质量,统计两组不良反应发生情况。结果:观察组总有效率高于对照组(P<0.05);两组治疗前及治疗2周的匹兹堡睡眠质量指数(PSQI)、汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分比较,差异均无统计学意义(P>0.05);治疗4、8、12周,观察组PSQI、HAMA及HAMD评分均较对照组低(P<0.05);两组治疗2、4、8、12周的副反应量表(TESS)评分比较,差异均无统计学意义(P>0.05)。结论:失眠症患者采用阿戈美拉汀+认知行为疗法联合针刺治疗效果显著,可有效提高患者的睡眠质量,改善焦虑抑郁状况,且不会增加不良反应,安全性好。

Objective:To investigate the effect of Agomelatine+cognitive behavioral therapy combined with acupuncture in patients with insomnia.Method:A total of 68 patients with insomnia who were admitted to the Third People’s Hospital of Ganzhou from August 2021 to February 2022 were selected and divided into two groups according to the random number table method,with 34 cases in each group.The control group was treated with Agomelatine+cognitive behavioral therapy,and the observation group was treated with Agomelatine+cognitive behavioral therapy combined with acupuncture.Both groups were treated continuously for 12 weeks.The therapeutic effects of the two groups were evaluated.The anxiety and depression status and sleep quality of the two groups were evaluated before treatment,2,4,8 and 12 weeks after treatment.The adverse reactions in the two groups were counted.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05).There were no significant differences in the scores of Pittsburgh sleep quality index(PSQI),Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)between the two groups before treatment and after 2 weeks of treatment(P>0.05).After 4,8 and 12 weeks of treatment,the scores of PSQI,HAMA and HAMD in the observation group were lower than those in the control group(P<0.05).There were no significant differences in treatment emergent symptom scale(TESS)scores between the two groups after 2,4,8 and 12 weeks of treatment(P>0.05).Conclusion:Agomelatine+cognitive behavioral therapy combined with acupuncture has a significant effect in patients with insomnia,which can effectively improve the sleep quality of patients and improve anxiety and depression status.Moreover,it does not increase adverse reactions,with good safety.