维生素D与肾病综合征相关性研究进展

Progress in the Correlation between Vitamin D and Nephrotic Syndrome

肾病综合征是一类好发于儿童期间的肾脏疾病,患儿在发病和激素治疗过程中均容易发生血清维生素D水平下降,而引发一系列病理生理改变。目前认为,应用维生素D防治肾病综合征能够改善患儿免疫水平、足细胞功能、骨代谢和蛋白尿等,不仅有利于恢复肾脏功能,也对疾病带来的其他系统损害起到一定防治作用。因此,本文就肾病综合征患儿血清维生素D水平下降机制,以及予患儿补充外源性维生素D的作用机制进行综述,期望能够服务于临床。

Nephrotic syndrome is a kind of kidney disease that occurs in children.In the course of disease and hormone therapy,the serum vitamin D level of children is prone to decrease,which leads to a series of pathophysiological changes.At present,it is believed that the application of vitamin D to prevent and treat nephrotic syndrome can improve the immune level,podocyte function,bone metabolism and proteinuria in children,which is not only conducive to restoring kidney function,but also play a certain role in the prevention and treatment of other system damage caused by the disease.Therefore,the present review of the mechanism of decreased serum vitamin D levels in children with nephrotic syndrome,and the mechanism of action of exogenous vitamin D supplementation in children,is expected to serve the clinical practice.