多奈哌齐片联合尼麦角林治疗血管性痴呆的临床效果及机制探讨

Clinical effects and mechanisms of donepezil tablets combined with nicergoline in the treatment of vascular dementia

目的探讨多奈哌齐片联合尼麦角林治疗血管性痴呆的临床效果及机制。方法66例血管性痴呆住院患者,随机分为观察组和对照组,每组33例。对照组患者给予多奈哌齐片治疗,观察组患者在对照组基础上联合尼麦角林治疗。比较两组患者治疗前后简易智力状态检查量表(MMSE)、日常生活能力量表(ADL)评分及临床疗效、不良反应发生情况。结果治疗后,观察组患者的MMSE评分、ADL评分分别为(25.18±4.13)、(59.20±7.62)分,均显著高于对照组的(20.55±2.87)、(51.27±6.54)分,差异具有统计学意义(P<0.05)。观察组患者的临床显效率、总有效率分别为36.36%、93.94%,均明显高于对照组的12.12%、72.73%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为6.06%,稍高于对照组的3.03%,但差异无统计学意义(P>0.05)。结论多奈哌齐片联合尼麦角林治疗血管性痴呆具有较为肯定的疗效,对改善患者临床症状以及促进生活质量提高均具有积极意义,值得临床广泛推广应用。

Objective To discuss the clinical effects and mechanisms of donepezil tablets combined with nicergoline in the treatment of vascular dementia.Methods A total of 66 inpatients with vascular dementia were randomly divided into observation group and control group,with 33 cases in each group.Patients in the control group were treated with donepezil tablets,and patients in the observation group were treated with nicergoline on the basis of the control group.Both groups were compared in terms of Mini-Mental Status Examination Scale(MMSE)and the Activities of Daily Living Scale(ADL)score before and after treatment,clinical efficacy,and the occurrence of adverse reactions.Results After treatment,the MMSE scores and ADL scores of patients in the observation group were(25.18±4.13)and(59.20±7.62)points,which were significantly higher than(20.55±2.87)and(51.27±6.54)points in the control group,and the differences were statistically significant(P<0.05).The clinical effective rate and total effective rate of patients in the observation group were 36.36%and 93.94%,which were significantly higher than 12.12%and 72.73%in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 6.06%,which was slightly higher than 3.03%in the control group,but the difference was not statistically significant(P>0.05).Conclusion Donepezil tablets combined with nicergoline has a definite effect on vascular dementia,and has a positive significance in improving the clinical symptoms and promoting the quality of life of patients,which is worthy of clinical promotion and application.