盐酸氨溴索联合头孢呋辛钠治疗小儿肺炎的临床效果研究

Study the clinical effect of ambroxol hydrochloride combined with cefuroxime sodium in the treatment of pneumonia in children

目的研究盐酸氨溴索联合头孢呋辛钠治疗小儿肺炎的临床效果。方法60例肺炎患儿,依据治疗方式不同分为实验组与对照组,每组30例。对照组患儿应用维生素C联合头孢呋辛钠进行治疗,实验组患儿应用盐酸氨溴索联合头孢呋辛钠治疗。对比两组患儿的临床疗效、临床症状消失时间与炎性因子[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-17(IL-17)、降钙素原(PCT)]水平。结果实验组患儿总有效率为96.67%,高于对照组的73.33%,差异具有统计学意义(P<0.05)。实验组患儿咳痰消失时间、咳嗽消失时间、喘息消失时间、肺部湿啰音消失时间分别为(4.28±2.20)、(6.51±1.59)、(3.22±1.31)、(5.67±1.55)d,均短于对照组的(7.07±3.19)、(8.49±2.02)、(5.07±1.00)、(6.93±1.79)d,差异具有统计学意义(P<0.05)。治疗后,实验组患儿IL-6(18.91±5.32)μg/L、IL-10(16.47±2.83)pg/ml、IL-17(6.05±1.13)pg/ml、PCT(0.18±0.04)ng/ml低于对照组的(29.41±6.01)μg/L、(20.33±3.21)pg/ml、(12.14±2.22)pg/ml、(0.31±0.03)ng/ml,差异均具有统计学意义(P<0.05)。结论盐酸氨溴索联合头孢呋辛钠治疗小儿肺炎效果显著,可有效改善炎性因子水平,缩短临床症状消失时间,值得临床推广应用。

Objective To study the clinical effect of ambroxol hydrochloride combined with cefuroxime sodium in the treatment of pneumonia in children.Methods A total of 60 children with pneumonia were divided into the experimental group and the control group according to the different treatment methods,with 30 cases in each group.Children in the control group were treated with vitamin C and cefuroxime sodium,and children in the experimental group were treated with ambroxol hydrochloride and cefuroxime sodium.Both groups were compared in terms of clinical efficacy,disappearance time of clinical symptoms and inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),interleukin-17(IL-17),procalcitonin(PCT)]levels.Results The total effective rate of the children in the experimental group was 96.67%,which was higher than 73.33%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of expectoration,cough,wheeze and wet rales in the lungs of the children in the experimental group were(4.28±2.20),(6.51±1.59),(3.22±1.31)and(5.67±1.55)d,which were shorter than(7.07±3.19),(8.49±2.02),(5.07±1.00)and(6.93±1.79)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the IL-6(18.91±5.32)μg/L,IL-10(16.47±2.83)pg/ml,IL-17(6.05±1.13)pg/ml and PCT(0.18±0.04)ng/ml in the experimental group were lower than(29.41±6.01)μg/L,(20.33±3.21)pg/ml,(12.14±2.22)pg/ml and(0.31±0.03)ng/ml in the control group,and the differences were all statistically significant(P<0.05).Conclusion Ambroxol hydrochloride combined with cefuroxime sodium in the treatment of pediatric pneumonia is very significant,and can effectively improve the level of inflammatory factors,shorten the disappearance time of clinical symptoms,which is worthy of clinical promotion and application.