宫腔镜手术联合去氧孕烯炔雌醇片治疗子宫内膜息肉患者的效果

Effect of Hysteroscopic Surgery Combined with Desogestrel and Ethinylestradiol Tablets in the Treatment of Endometrial Polyps

目的:探讨宫腔镜手术联合去氧孕烯炔雌醇片治疗子宫内膜息肉(EMP)患者的效果。方法:选取广西壮族自治区江滨医院妇产科2017年2月-2021年2月收治的70例EMP患者为研究对象,按照随机数字表法分为观察组(n=35)和对照组(n=35)。对照组采用宫腔镜下子宫内膜息肉切除术(TCRP)进行治疗,观察组在对照组基础上术后服用去氧孕烯炔雌醇片3个疗程。观察比较两组月经量、子宫内膜厚度、血清性激素水平及随访情况。结果:两组术后6、12个月月经量均较治疗前减少,且观察组均少于对照组(P<0.05);术后6、12个月观察组子宫内膜厚度均小于对照组(P<0.05);两组促卵泡生成素(FSH)、孕酮(P)、雌二醇(E_(2))水平均较治疗前降低,且观察组均低于对照组(P<0.05);观察组复发率较对照组低(P<0.05)。结论:宫腔镜下TCRP联合去氧孕烯炔雌醇片治疗EMP患者可以有效控制月经量、子宫内膜厚度,降低血清性激素水平,且能有效减少EMP复发。

Objective:To investigate the effect of hysteroscopic surgery combined with Desogestrel and Ethinylestradiol Tablets in the treatment of endometrial polyps(EMP).Method:A total of 70 patients with EMP who were admitted to the Department of Obstetrics and Gynecology,Jiangbin Hospital of Guangxi Zhuang Autonomous Region from February 2017 to February 2021 were selected as the research subjects and divided into an observation group(n=35)and a control group(n=35)according to the random number table method.The control group was treated with hysteroscopic transcervical resection of polyps(TCRP),and the observation group was treated with Desogestrel and Ethinylestradiol Tablets for three courses after operation.Menstrual flow,endometrial thickness,serum sex hormone levels and follow-up were observed and compared between the two groups.Result:6,12 months after surgery,the menstrual flow in both groups decreased compared with that before treatment,and the observation group were less than those in the control group(P<0.05).6,12 months after surgery,the endometrial thickness in the observation group were less than those in the control group(P<0.05).The levels of follicle stimulating hormone(FSH),progesterone(P)and estradiol(E_(2))in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The recurrence rate in the observation group was lower than that in the control group(P<0.05).Conclusion:Hysteroscopic TCRP combined with Desogestrel and Ethinylestradiol Tablets in the treatment of patients with EMP can effectively control menstrual flow and endometrial thickness,reduce serum sex hormone levels,and effectively reduce the recurrence of EMP.