肠道微生态制剂联合间歇蓝光照射对高胆红素血症新生儿血清胆红素水平的影响

Effect of intestinal microecological preparations combined with intermittent blue light irradiation on serum bilirubin levels in neonates with hyperbilirubinemia

目的探讨肠道微生态制剂联合间歇蓝光照射对高胆红素血症新生儿血清胆红素水平的影响。方法40例高胆红素血症患儿,以随机数字表法为依据分为对照组和观察组,每组20例。对照组患儿予以间歇蓝光照射治疗,观察组患儿在对照组基础上加用地衣芽孢杆菌活菌颗粒治疗。比较两组患儿治疗效果,蓝光照射时间、黄疸消退时间、血清胆红素水平日均下降量,不同时间血清胆红素水平。结果治疗后,观察组患儿的临床总有效率90.00%高于对照组的60.00%,差异有统计学意义(P<0.05)。观察组患儿蓝光照射时间(32.95±4.17)h、黄疸消退时间(3.94±0.57)d均短于对照组的(53.12±6.26)h、(7.63±0.93)d,血清胆红素水平日均下降量(59.42±6.23)μmol/L高于对照组的(28.91±4.30)μmol/L,差异有统计学意义(P<0.05)。治疗前,两组血清胆红素水平比较差异无统计学意义(P>0.05);治疗3、5、7 d后,两组血清胆红素水平较本组治疗前呈逐渐降低趋势,且观察组血清胆红素水平低于对照组,差异有统计学意义(P<0.05)。结论肠道微生态制剂联合间歇蓝光照射治疗高胆红素血症新生儿的临床效果显著,可缩短临床症状缓解时间,降低血清胆红素水平。

Objective To discuss the effect of intestinal microecological preparations combined with intermittent blue light irradiation on serum bilirubin levels in neonates with hyperbilirubinemia.Methods A total of 40 neonates with hyperbilirubinemia were divided into a control group and an observation group according to the random numerical table,with 20 cases in each group.Children in the control group were treated with intermittent blue light irradiation,and children in the observation group were treated with live Bacillus licheniformis granules on the basis of the control group.Both groups were compared in terms of therapeutic effect,the time of blue light irradiation,the time of jaundice subsidence,the average daily decrease of serum bilirubin level,and the serum bilirubin level at different time points.Results After treatment,the total clinical efficiency in the observation group was 90.00%,which was higher than 60.00%in the control group,and the difference was statistically significant(P<0.05).The time of blue light irradiation(32.95±4.17)h and the time of jaundice subsidence(3.94±0.57)d in the observation group were shorter than(53.12±6.26)h and(7.63±0.93)d in the control group;the average daily decrease of serum bilirubin level(59.42±6.23)μmol/L in the observation group was higher than(28.91±4.30)μmol/L in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in serum bilirubin levels between the two groups(P>0.05).After 3,5 and 7 d of treatment,the serum bilirubin levels in the two groups showed a gradual decrease compared with those before treatment in this group,and the serum bilirubin levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical effect of intestinal microecological preparation combined with intermittent blue light irradiation in the treatment of neonates with hyperbilirubinemia is remarkable,which can shorten the remission time of clinical symptom and reduce serum bilirubin level.