重复经颅磁刺激联合西酞普兰治疗老年抑郁症的效果观察

Observation on the effect of repeated transcranial magnetic stimulation combined with citalopram in the treatment of senile depression

目的分析重复经颅磁刺激(r TMS)联合西酞普兰治疗老年抑郁症的临床疗效。方法120例老年抑郁症患者为研究对象,随机分为观察组与对照组,各60例。对照组采用西酞普兰治疗,观察组在对照组基础上联合rTMS治疗。比较两组治疗效果、不良反应发生情况及治疗前后抑郁情况。结果观察组治疗总有效率95.00%高于对照组的75.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗2、4周,两组汉密尔顿抑郁量表(HAMD)评分均低于本组治疗前,且观察组HAMD评分分别为(18.20±4.50)、(14.50±2.50)分,均低于对照组的(23.20±5.60)、(20.02±3.50)分,差异均有统计学意义(P<0.05)。结论rTMS联合西酞普兰治疗老年抑郁症具有安全性、有效性,促进患者抑郁症状改善。

Objective To analyze the clinical efficacy of repeated transcranial magnetic stimulation(rTMS)combined with citalopram in the treatment of senile depression.Methods A total of 120 elderly patients with depression were studied and randomly divided into observation group and control group,with 60 cases in each group.The control group was treated with citalopram,and the observation group was treated with rTMS on the basis of the control group.The therapeutic effect,occurrence of adverse reactions and depression before and after treatment were compared between the two groups.Results The total effective rate of observation group was 95.00%,which was higher than 75.00%of control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 2 and 4 weeks of treatment,the HAMD scores in both groups were lower than those before treatment in this group;the HAMD scores in the observation group were(18.20±4.50)and(14.50±2.50)points,which were lower than(23.20±5.60)and(20.02±3.50)points in the control group;the differences were statistically significant(P<0.05).Conclusion rTMS combined with citalopram is safe and effective in the treatment of senile depression,and it can promote the improvement of patients’depressive symptoms.