含铋剂四联疗法治疗幽门螺杆菌阳性消化性溃疡的临床效果

Clinical effect of bismuth-containing quadruple therapy on Helicobacter pylori-positive peptic ulcer

目的研究含铋剂四联疗法治疗幽门螺杆菌阳性消化性溃疡的作用。方法80例幽门螺杆菌阳性消化性溃疡患者,以随机方法分为观察组与对照组,各40例。对照组采用常规疗法进行治疗,观察组采用含铋剂四联疗法治疗。比较两组患者治疗效果以及治疗前后的炎性因子[白细胞介素-35(IL-35)、白细胞介素-18(IL-18)、C反应蛋白(CRP)]水平。结果观察组治疗总有效率95.00%高于对照组的72.50%,差异具有统计学意义(P<0.05)。治疗后,观察组患者IL-18(70.82±11.22)pg/ml、IL-35(219.86±16.33)pg/ml、CRP(1.35±0.84)mg/L均优于对照组的(85.63±10.83)pg/ml、(203.11±11.35)pg/ml、(13.54±4.78)mg/L,差异有统计学意义(P<0.05)。结论对幽门螺杆菌阳性消化性溃疡患者通过含铋剂四联疗法治疗可以有效提升患者的治疗效果,降低机体内的炎症反应,值得推荐。

Objective To study the effect of bismuth-containing quadruple therapy on Helicobacter pylori-positive peptic ulcer.Methods A total of 80 patients with Helicobacter pylori-positive peptic ulcer were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with bismuth-containing quadruple therapy.Both groups were compared in terms of therapeutic effects,the levels of inflammatory factors[interleukin-35(IL-35),interleukin-18(IL-18),and C-reactive protein(CRP)]before and after treatment.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 72.50%in the control group,and the difference was statistically significant(P<0.05).After treatment,the IL-18(70.82±11.22)pg/ml,IL-35(219.86±16.33)pg/ml and CRP(1.35±0.84)mg/L in the observation group were better than(85.63±10.83)pg/ml,(203.11±11.35)pg/ml and(13.54±4.78)mg/L in the control group,and the differences were statistically significant(P<0.05).Conclusion For patients with Helicobacter pylori-positive peptic ulcer,bismuth-containing quadruple therapy can effectively improve the therapeutic effect and reduce the inflammatory response in the body,which is worth recommending.