帕罗西汀与西酞普兰治疗脑卒中后抑郁症的效果分析

Effect analysis of paroxetine and citalopram in the treatment of post-stroke depression

目的比较帕罗西汀与西酞普兰治疗脑卒中后抑郁症的临床疗效。方法62例脑卒中后抑郁症患者,以随机数字表法分为甲组和乙组,各31例。甲组患者采取西酞普兰治疗,乙组患者采取帕罗西汀片治疗。比较两组患者治疗效果、不良反应发生率及治疗前后抑郁程度、神经功能改善情况。结果甲组患者治疗总有效率83.87%与乙组的77.42%比较,差异无统计学意义(P>0.05)。治疗后,甲组患者抑郁因子评分(4.35±2.54)分、睡眠因子评分(2.05±1.14)分、焦虑/躯体症状评分(3.78±2.20)分及总分(12.02±2.67)分与乙组的(4.17±2.50)、(1.96±1.11)、(3.71±2.20)、(12.34±2.74)分比较,差异均无统计学意义(P>0.05)。治疗后,甲组患者斯堪的纳维亚脑卒中量表(SSS)评分(8.27±1.74)分与乙组的(9.05±1.84)分比较,差异无统计学意义(P>0.05)。甲组患者不良反应发生率16.13%(5/31)与乙组的22.58%(7/31)比较,差异无统计学意义(P>0.05)。结论帕罗西汀与西酞普兰治疗脑卒中后抑郁症均具有较好的疗效,治疗安全性也较高,具体用药要根据患者实际病情选择。

Objective To compare the clinical efficacy of paroxetine and citalopram in the treatment of post-stroke depression.Methods A total of 62 patients with post-stroke depression were divided into group A and group B according to the random numerical table,with 31 cases in each group.Patients in group A were treated with citalopram,and patients in group B were treated with paroxetine tablets.The therapeutic effect,incidence of adverse reactions,depression degree and improvement of neurological function before and after treatment were compared between the two groups.Results The total effective rate in group A was 83.87%,and the difference was not statistically significant compared with 77.42%in group B(P>0.05).After treatment,group A had depression factor score of(4.35±2.54)points,sleep factor score of(2.05±1.14)points,anxiety/somatic symptom score of(3.78±2.20)points and total score of(12.02±2.67)points,and the when compared with(4.17±2.50),(1.96±1.11),(3.71±2.20),(12.34±2.74)points in group B(P>0.05).After treatment,the Scandinavian Stroke Scale(SSS)score was(8.27±1.74)points in group A and(9.05±1.84)points in group B,and the difference was statistically significant(P>0.05).The incidence of adverse reactions was 16.13%(5/31)in group A,and 22.58%(7/31)in group B,and the difference was statistically significant(P>0.05).Conclusion Paroxetine and citalopram are effective and safe in the treatment of post-stroke depression,and the specific medication should be selected according to the actual condition of the patient.