非酒精性脂肪性肝病与冠心病的相关性

Correlation analysis between non-alcoholic fatty liver disease and coronary heart disease

目的:分析非酒精性脂肪性肝病(NAFLD)与冠心病(CAD)的发病、严重程度的相关性,为CAD的预防及诊治提供依据。方法:选取泰州市人民医院疑似或者确诊CAD的患者为研究对象,行腹部B超检查以及经皮冠状动脉造影检查,根据冠脉造影结果共分为CAD组(n=365)与非CAD组(n=137),观察脂肪肝在两组中的患病率有无差异,分析CAD的患病独立危险因素。对CAD组的患者根据有无脂肪肝将其分为脂肪肝组(n=167)与非脂肪肝组(n=198),研究两组Gensini评分有无差异。结果:CAD组的NAFLD患病率与非CAD组的NAFLD患病率比较,差异有统计学意义(P<0.001),NAFLD是CAD患病的独立危险因素(OR=2.42>1,95%CI:1.46~4.01)。在CAD患者中,NAFLD组的Gensini评分显著高于非NAFLD组(P=0.011)。结论:NAFLD为CAD发病的独立危险因素;NAFLD与冠状动脉病变严重程度密切相关。

Objective To provide evidence for the prevention and treatment of coronary heart disease(CHD)by analyzing the correlation between the incidence and severity of non-alcoholic fatty liver disease(NLD)and coronary atherosclerotic heart disease.Method The patients with suspected or confirmed coronary heart disease were selected as the research object,and underwent abdominal B-ultrasonography and percutaneous coronary angiography.According to the results of coronary angiography,they were divided into two groups:coronary heart disease group(n=365)and non-coronary heart disease group(n=137).To observe whether the prevalence of fatty liver was different between the two groups,and to analyze the independent risk factors of coronary heart disease.The patients in the CHD group were divided into fatty liver group(n=167)and non-fatty liver group(n=198)according to whether there was a difference in Gensini score between the two groups.Results The prevalence of nonalcoholic fatty liver disease in the coronary heart disease group was significantly different from that in the non-coronary heart disease group(P<0.001).NAFLD was an independent risk factor for CAD(OR=2.42>1,95%CI:1.46~4.01).In CHD patients,the Gensini score in NAFLD group was significantly higher than that in non-NAFLD group(P=0.011).Conclusion NAFLD is an independent risk factor for CAD.NAFLD is closely related to the severity of coronary artery disease.