盐酸多奈哌齐片联合司来吉兰片治疗老年帕金森病患者的效果

Effects of Donepezil hydrochloride tablets combined with Selegiline tablets in treatment of elderly patients with Parkinson’s disease

目的:观察盐酸多奈哌齐片联合司来吉兰片治疗老年帕金森病(PD)患者的效果。方法:选取2021年3月至2022年3月该院收治的90例老年PD患者进行前瞻性研究,以随机数字表法将其分为观察组和对照组各45例。对照组给予司来吉兰片治疗,观察组在对照组基础上联合盐酸多奈哌齐片治疗,比较两组治疗前后认知功能[蒙特利尔认知评估量表(MoCA)]评分、症状改善情况[帕金森氏病综合评分量表(UPDRS)]评分、日常活动能力[Barthel指数(BI)]评分、治疗效果、治疗前后氧化应激指标[血清谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平和治疗期间不良反应发生率。结果:治疗后,观察组MoCA和BI评分均高于对照组,UPDRS评分低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.56%(43/45),高于对照组的80.00%(36/45),差异有统计学意义(P<0.05);治疗后,观察组MDA水平低于对照组,GSH和SOD水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸多奈哌齐片联合司来吉兰片治疗PD患者可提高治疗总有效率、MoCA评分和BI评分,降低UPDRS评分,改善氧化应激指标水平,效果优于单纯司来吉兰片治疗。

Objective:To observe effects of Donepezil hydrochloride tablets combined with Selegiline tablets in treatment of elderly patients with Parkinson’s disease(PD).Methods:A prospective study was conducted on 90 elderly PD patients admitted to the hospital from March 2021 to March 2022.They were randomly divided into observation group and control group by using the digital table method,45 cases in each.The control group was treated with Selegiline tablets,while the observation group was treated with Donepezil hydrochloride tablets on the basis of that of the control group.The cognitive function[Montreal cognitive assessment(MoCA)]score,the symptom improvement[unified Parkinson’s disease rating scale(UPDRS)]score,the activities of daily living[Barthel Index(BI)]score,the treatment effect,the oxidative stress index levels[serum glutathione(GSH),malondialdehyde(MDA),superoxide dismutase(SOD)]before and after treatment,and the incidence of adverse reactions during the treatment were compared between the two group.Results:After the treatment,the MoCA and the BI scores of the observation group were higher than those of the control group,the UPDRS score was lower than that of the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.56%(43/45),which was higher than 80.00%(36/45)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the level of MDA in the observation group was lower than that in the control group,the levels of GSH and SOD were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Donepezil hydrochloride tablets combined with Selegiline tablets in the treatment of the PD patients can improve the total effective rate of treatment,the MoCA scores and the BI scores,reduce the UPDRS scores and improve the levels of oxidative stress indexes.Moreover,it is superior to single Selegiline tablets treatment.