化瘀消癥汤、米非司酮、氨甲蝶呤三联治疗宫外孕患者的效果

Effects of Huayu Xiaozheng decoction,Mifepristone and Methotrexate triple therapy on patients with ectopic pregnancy

目的:观察化瘀消癥汤、米非司酮、氨甲蝶呤三联治疗宫外孕患者的效果。方法:选取2018年3月至2020年6月该院收治的66例宫外孕患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各33例。对照组采用米非司酮联合氨甲蝶呤注射剂治疗,观察组在对照组基础上增加化瘀消癥汤治疗。比较两组疗效,治疗前后血清人绒毛膜促性腺激素(β-HCG)、糖类抗原125(CA125)、孕酮水平,血清β-HCG水平恢复正常时间,住院时间,以及并发症发生率。结果:治疗后,两组血清CA125水平均低于治疗前,且观察组低于对照组,两组孕酮水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后5、10 d,两组β-HCG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后15、30 d,两组β-HCG水平均低于治疗前,但两组间比较,差异无统计学意义(P>0.05);观察组治疗总有效率为87.88%,明显高于对照组的63.64%,差异有统计学意义(P<0.05);观察组不良反应发生率为9.09%,明显低于对照组的30.30%,差异有统计学意义(P<0.05);观察组血清β-HCG恢复正常时间和住院时间均短于对照组,差异有统计学意义(P<0.05)。结论:化瘀消癥汤、米非司酮、氨甲蝶呤三联治疗宫外孕患者可提高治疗总有效率和孕酮水平,降低CA125、β-HCG水平和不良反应发生率,缩短血清β-HCG恢复正常时间和住院时间,优于米非司酮联合氨甲蝶呤治疗效果。

Objective:To observe effects of Huayu Xiaozheng decoction,Mifepristone and Methotrexate triple therapy on patients with ectopic pregnancy.Methods:A prospective study was conducted on 66 patients with ectopic pregnancy admitted to the hospital from March 2018 to June 2020.They were divided into control group and observation group according to the random number table method,33 cases in each.The control group was treated with Mifepristone combined with Methotrexate injection,while the observation group was treated with Huayu Xiaozheng decoction on the basis of that of the control group.The efficacy,the serumβ-HCG level,the CA125 level,the progesterone level,the serumβ-HCG level recovery time,the hospitalization time,and the incidence of complications were compared between the two groups before and after the treatment.Results:After the treatment,the serum CA125 levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the progesterone levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).5 and 10 days after the treatment,the levels ofβ-HCG in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).15 and 30 days after the treatment,the levels ofβ-HCG in the two groups were lower than those before the treatment;however,there was no significant difference between the two groups(P>0.05).The total effective rate of treatment in the observation group was 87.88%,which was significantly higher than 63.64%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 9.09%,which was lower than 30.30%in the control group,and the difference was statistically significant(P<0.05).Further,the recovery time of serumβ-HCG level and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Huayu Xiaozheng decoction,Mifepristone and Methotrexate in the treatment of ectopic pregnancy can improve the total effective rate and the progesterone levels,reduce the CA125 levels,theβ-HCG levels and the incidence of adverse reactions,and shorten the recovery time of serumβ-HCG level and the hospitalization time.Moreover,it is superior to Mifepristone combined with Methotrexate treatment.