2型糖尿病合并骨质疏松危险因素Logistic回归分析

Logistic Regression Analysis of Risk Factors for Osteoporosis in Type 2 Diabetes Mellitus

目的探讨2型糖尿病合并骨质疏松的危险因素。方法选择2019年9月—2022年9月在厦门医学院附属第二医院内分泌科住院的2型糖尿病患者分为非骨质疏松组和骨质疏松组。对两组的临床资料和实验室数据进行单因素分析。将单因素分析中有统计学意义以及临床经验考虑相关的影响因素纳入多因素二元Logistic回归模型中进行分析。结果两组的性别、年龄、身体质量指数(body mass index,BMI)、吸烟、高血压、同型半胱氨酸(homocysteine,Hcy)、尿微量白蛋白肌酐比值(urine albumin creatinine ratio,UACR)差异有统计学意义(P<0.05)。二元Logistic回归分析显示,女性、年龄大、吸烟、合并高血压、尿微量白蛋白肌酐比值为2型糖尿病合并骨质疏松的危险因素(OR>1,P<0.05),高BMI为保护因素(OR<1,P<0.05)。结论2型糖尿病合并骨质疏松的危险因素众多,其中女性、年龄大、吸烟、合并高血压、高尿微量白蛋白肌酐比值为危险因素,高BMI为保护因素。

Objective To investigate the risk factors of type 2 diabetes mellitus with osteoporosis.Methods Patients with type 2 diabetes who admitted to the department of Endocrinology of the Second Affiliated Hospital of Xiamen Medical College from September 2019 to September 2022 were divided into nonosteoporosis group and osteoporosis group.The clinical data and laboratory data of the two groups were analyzed by univariate analysis.Factors that were statistically significant in univariate analysis and considered relevant to clinical experience were incorporated into the multivariate binary Logistic regression model for analysis.Results Sex,age,body mass index(BMI),smoking,hypertension,homocysteine(Hcy),urine albumin creatinine ratio(UACR)of the two groups had statistical significance(P<0.05).Binary Logistic regression analysis showed that female,older age,smoking,hypertension,high urine albumin-creatinine ratio were risk factors for type 2 diabetes mellitus with osteoporosis(OR>1,P<0.05),and high BMI was a protective factor(OR<1,P<0.05).Conclusion There are many risk factors for type 2 diabetes mellitus with osteoporosis,among which female,older age,smoking,hypertension,high urinary albumin-creatinine ratio are risk factors,high BMI is a protective factor.