脑肿瘤患者认知功能现状及其相关危险因素分析

Current status and risk factors of cognitive function in patients with brain tumors

目的 分析脑肿瘤患者认知功能现状及其相关危险因素.方法 选择2021年1月-2022年4月期间南昌大学第二附属医院收治的脑肿瘤患者85例为研究对象,采用蒙特利尔认知评估量表(MoCA)评估患者认知功能状况,将MoCA评分≥26分的脑肿瘤患者纳入正常组,将MoCA评分<26分的脑肿瘤患者纳入异常组.采用基线资料调查问卷记录患者一般资料并比较,找出可能影响肿瘤患者认知功能的危险因素.结果 85例脑肿瘤患者中45例伴有认知功能障碍,发生率为52.94%;两组年龄、文化程度、WHO肿瘤病理分级、焦虑抑郁情绪比较,差异有统计学意义(P<0.05);经多项Logistics回归分析结果显示,年龄大、文化程度低、WHO肿瘤病理分级高、伴有焦虑抑郁情绪是影响肿瘤患者认知功能障碍的危险因素(OR>1,P<0.05).结论 肿瘤患者认知功能障碍发生率较高,可能受到患者年龄大、文化程度低、肿瘤病理分级高及焦虑抑郁情绪等危险因素影响.

Objective To analyze the status of cognitive function and related risk factors in patients with brain tumors.Methods Eightyfive patients with brain tumors admitted to the hospital from January 2021 to April 2022 were selected as the research objects.Montreal Cognitive Assessment(MoCA)was used to evaluate the cognitive function of patients.Brain tumor patients with MoCA score≥26 were included in the normal group,and brain tumor patients with MoCA score<26 were included in the abnormal group.Baseline data questionnaire was used to record the general data of patients and compare them to find out the risk factors that may affect the cognitive function of cancer patients.Results Among 85 patients with brain tumor,45 had cognitive dysfunction(52.94%).There were significant differences in age,education level,WHO tumor pathological grade,anxiety and depression between the two groups(P<0.05).The results of multiple logistics regression analysis showed that older age,lower education level,higher WHO tumor pathological grade,accompanied by anxiety and depression were the risk factors of cognitive dysfunction in cancer patients(OR>1,P<0.05).Conclusions The incidence of cognitive dysfunction in cancer patients is high,which may be affected by risk factors such as older age,lower education level,higher tumor pathological grade,anxiety and depression.