我院头孢菌素类药物的较重不良反应发生原因及处理分析

Analysis of the causes and treatment of serious adverse reactions of cephalosporinins in our hospital

目的 归纳总结头孢菌素类药物引起较重不良反应的具体情况,分析原因并提出预防处理对策.方法 针对句容市天王中心卫生院2019年2月-2022年2月药剂科内头孢菌素类药物处方5000份进行回顾性研究,统计患者用药后出现较重不良反应的具体情况与概率,结合患者个人因素、药品种类、给药途径等情况归纳引起不良反应的具体原因,同时提出合理的预防处理方案.结果 此次5000份头孢菌素类药物处方中,共计15例患者出现较重不良反应,发生率为0.30%,其中,饮酒,第二、三代头孢菌素药物及静脉用药更易诱发不良反应.结论 头孢菌素类药物使用不当容易诱发多种不良反应,临床用药前应叮嘱患者禁饮酒,同时合理选择药物种类及给药途径,保障患者用药安全.

Objective To summarize the specific situation of serious adverse reactions caused by cephalosporins,analyze the reasons and put forward preventive countermeasures.Methods A retrospective study was carried out on 5000 cephalosporin prescriptions in the pharmacy of our hospital from February 2019 to February 2022.The specific situation and probability of severe adverse reactions after drug use were counted.The specific causes of adverse reactions were summarized in combination with the patient's personal factors,drug types,administration routes,etc.,and a reasonable prevention and treatment plan was proposed.Results Of the 5000 cephalosporin prescriptions,15 patients had serious adverse reactions,with an incidence of 0.30%.Among them,alcohol consumption,second-generation and third-generation cephalosporin drugs and intravenous drugs were more likely to induce adverse reactions.Conclusion Inappropriate use of cephalosporins is likely to induce a variety of adverse reactions.Before clinical use,patients should be advised not to drink,and at the same time,drug types and administration routes should be reasonably selected to ensure the safety of patients.