新四联治疗射血分数低下心力衰竭临床体会

Clinical Efficacy of New Quadruple Therapy in the Treatment of Chronic Heart Failure with Decreased Ejection Fraction

目的探讨新四联治疗慢性射血分数低下心力衰竭的疗效.方法回顾性选取1999年3月-2022年4月期间在八里庄第二社区卫生服务中心及小红门社区卫生服务中心住院或门诊接受治疗的16例HFrEF患者作为研究对象,共观察三个月.在标准抗心衰药物基础上给予新四联治疗,对比新四联药物治疗前后血压、心率、体质量(kg)、24h尿量(ml),服用利尿剂剂量(mg/d)、NT-proBNP、6分钟步行试验及心功能变化,并密切观察患者药物不良反应.结果新四联治疗慢性射血分数低下心力衰竭,可明显改善患者临床症状、心功能,患者体质量、服用利尿剂剂量、NT-proBNP水平均降低,24h尿量增加,左室舒张末内径(LVEDD)减少、左室射血分数(LVEF)及六分钟步行距离均增加.结论新四联药物治疗慢性射血分数低下心力衰竭可进一步减轻钠水潴留、改善患者临床症状及心功能.

Objective To observe the clinical efficacy of New Quadruple Therapy in the Treatment of Chronic Heart Failure with Decreased Ejection Fraction.Methods 16 patients with chronic heart failure with Left ventricular ejection fraction were enrolled in this study.Blood pressure,Data of body weight,24-hour urine volume,dosage of diuretics,N-terminal pro-brain natriuretic peptid(NT-proBNP)level before treatment and 3 month after treatment,and cardiac structure and function before treatment and three months after treatment were compared.Results New Quadruple Therapy in the Treatment of Chronic Heart Failure with Decreased Ejection Fraction can improve cardiac function.The body weight,diuretic dosage and NT-proBNP level decreased,24-hour urine volume increased,while left ventricular end-diastolic diameter(LVEDD)reduced,leff ventricular ejection fraction(LVEF)and the six-minute walking test increased.Conclus ion New Quadruple Therapy can further reduce water-sodium retention and improve cardiac function.