骨质疏松症与认知功能障碍相关性的Meta分析

Meta-Analysis of the Relationship Between Osteoporosis and Cognitive Impairment

目的系统评价骨质疏松症和认知功能障碍的相关性。方法计算机检索PubMed、Web of Science、EMbase、万方、维普和知网等数据库,搜索关于骨质疏松症和认知功能障碍相关性的研究。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,对所搜集数据采用RevMan5.3软件和Stata17.0软件进行统计分析。结果共纳入11项研究,包括8488例研究对象。Meta分析结果显示:骨质疏松症组认知功能障碍发病率更高(OR=1.92,95%CI:1.69~2.18)。结论骨质疏松症患者更易发生认知功能障碍,两者风险呈正相关。受纳入研究数量和质量限制,上述结论尚待更多高质量研究予以验证。

Objective To evaluate the correlation between osteoporosis and cognitive impairment.Methods PubMed,Web of Science,EMbase,Wanfang,VIP and CNKI databases were used to search for the studies on the relationship between osteoporosis and cognitive impairment.After two researchers independently screened the literature,extracted data and evaluated the bias risk,the collected data were analyzed using RevMan 5.3 software and Stata 17.0 software.Results A total of 11 studies were included in this analysis,including 8488 subjects.Meta-analysis showed that the incidence of cognitive impairment in the osteoporosis group was higher than that in the control group(OR=1.92,95%CI:1.69-2.18).Conclusion Patients with osteoporosis are vulnerable to cognitive impairment,and the risk of both is positively correlated.Limited by the number and quality of included studies,the above conclusion needs to be verified by more high-quality studies.