肿瘤相关巨噬细胞表面受体在口腔鳞癌发展中作用的研究进展

Research Progress on the Role of Tumor-associated Macrophage Surface Receptors in the Development of Oral Squamous Cell Carcinoma

口腔鳞状细胞癌(OSCC)发病率高,侵袭性强,预后差,多发生于60岁以上老年人。肿瘤相关巨噬细胞(TAMs)作为肿瘤微环境(TME)中重要的细胞成分之一,其表面受体在OSCC发展中具有重要作用。肿瘤细胞分泌的蛋白可以与TAMs表面受体结合,介导细胞信号通路使TAMs的表型或功能发生变化,进而影响肿瘤细胞的生物学行为,但具体机制尚未完全阐明。本文重点概述了TAMs表面受体在OSCC发展中作用的研究进展,并为OSCC的基础研究和临床治疗提供一定的理论依据。

Oral squamous cell carcinoma(OSCC) has a high morbidity, strong invasiveness and poor prognosis, and mainly occurs in elderly people over 60 years old.As an important cellular component of tumor microenvironment(TME),tumor associated macrophages(TAMs) play an important role in the development of OSCC.Proteins secreted by tumor cells binds to TAMs surface receptors and mediate cell signaling pathways to change the phenotype or function of TAMs, thus affecting the biological behavior of tumor cells.However, the specific mechanism has not been fully clarified.This review focuses on the role of TAMs surface receptors in the development of OSCC,and provides a theoretical basis for basic research and clinical treatment of OSCC.