电子鼻技术检测人呼出气挥发性有机物的研究进展

Research progress of electronic nose in detecting volatile organic compounds in human exhaled breath

挥发性有机化合物(Volatile Organic Compounds, VOCs)不仅存在于人类生活环境中,也会在人体代谢过程中产生,人体产生的VOCs的种类和峰度与人体健康和疾病状态密切相关。近年来,通过无创检测的方式分析人体呼出气中VOCs的组分和浓度可以用来指示人体健康状态,在临床诊断和健康监测领域得到广泛关注。综述了呼出气VOCs的临床检测应用价值和常见检测方法,描述了各种方法的利弊。详细阐述了新型电子鼻技术给呼出气VOCs检测带来的革命性进展,为呼出气VOCs的高灵敏、高通量、智能化检测带来了更多可能。

Volatile Organic Compounds(VOCs) are not only present in the human living conditions, but also can be produced in the process of human metabolism. The types and kurtosis of VOCs produced by the human body are closely related to human health and disease status. In recent years, analyzing VOCs components and concentration in human exhaled breath through noninvasive detection can be used to indicate human health status, which has been widely concerned in the field of clinical diagnosis and health monitoring. This paper reviews the clinical application value and common detection methods of exhaled VOCs, and elucidates pros and cons of each method. In this paper, the revolutionary progress brought by the new electronic nose technology to the detection of exhaled VOCs is described, which brings more possibilities for the high sensitivity, high throughput and intelligent detection of exhaled VOCs.