度普利尤单抗引起超敏反应1例报道并文献复习

Hypersensitivity induced by Dupilumab:a case report and literature review

本文报道广州市皮肤病防治所度普利尤单抗治疗特应性皮炎(atopic dermatitis,AD)导致超敏反应1例,并对相关文献进行复习总结。患者,男,58岁,因AD首次使用度普利尤单抗治疗,2 d后躯干四肢出现大片红斑和水疱,诊断为多形红斑型药疹。给予系统性甲泼尼松龙治疗后症状好转。度普利尤单抗引起的超敏反应表现是多种多样性的,我们回顾文献汇总类似病例报道并进行总结。

A case of hypersensitivity induced by Dupilumab in the treatment of atopic dermatitis(AD)in Guangzhou Institute of Dermatology was reported,and the relevant literatures were reviewed and summarized.A 58-year-old male patient was treated with Dupilumab for the first time due to AD.Large erythema and blisters appeared on the trunk and limbs 2 days later,and the drug eruption of multiform erythema was diagnosed.He was advised to take systemic methylprednisolone,then tapered slowly based on the response.Hypersensitivity induced by Dupilumab was diverse.We reviewed the literatures and summarized the similar case reports.