经颅直流电刺激联合常规康复训练治疗帕金森病的效果观察

Effect of transcranial direct current stimulation combined with routine rehabilitation training on Parkinson disease

目的探讨经颅直流电刺激联合常规康复训练治疗帕金森病的临床效果。方法抽取2019年9月至2021年10月驻马店市中心医院收治的帕金森病患者126例,按照随机数字表法分为常规治疗组与经颅直流电刺激组,每组63例。常规治疗组采用常规康复训练治疗,经颅直流电刺激组在其基础上加用经颅直流电刺激治疗。对比两组三维步态参数步频、步速、平衡能力、计时起立-行走测试(TUGT)、Barthel指数(BI)、跌倒效能量表(MFES)评分、简易智能状态检查量表(MMSE)及蒙特利尔认知评估量表(MoCA)评分。结果干预后,经颅直流电刺激组步频、步速快于常规治疗组(P<0.05);干预后,经颅直流电刺激组平衡能力评分[(34.51±3.26)分]高于常规治疗组[(26.32±2.81)分],TUGT时间[(9.46±0.71)s]短于对照组[(10.27±1.03)s],P<0.05;干预后,经颅直流电刺激组BI、MFES评分[(53.21±3.25)、(6.36±0.32)分]高于常规治疗组[(46.12±3.67)、(5.06±0.28)分],P<0.05;干预后,经颅直流电刺激组MMSE、MoCA评分[(26.75±2.05)、(26.59±1.96)分]高于常规治疗组[(25.67±1.95)、(25.12±1.87)分],P<0.05。结论经颅直流电刺激联合常规康复训练治疗帕金森病,可改善患者步行状况,增强平衡能力,提高生活自理能力,改善认知功能。

Objective To investigate the effect of transcranial direct current stimulation combined with routine rehabilitation training on Parkinson disease.Methods A total of 126 patients with Parkinson disease treated in Zhumadian Central Hospital from September 2019 to October 2021 were selected,and they were divided into conventional treatment group and transcranial direct current stimulation group according to the random number table method,with 63 cases in each group.The conventional treatment group was treated by conventional rehabilitation training,and the transcranial direct current stimulation group was additionally treated by transcranial direct current stimulation.The three-dimensional gait parameters,including stride frequency,stride speed,and balance ability,timed up and go test(TUGT),Barthel index(BI),modified falls efficacy scale(MFES)score,mini-Mental State Examination(MMSE),Montreal cognitive assessment(MoCA)score were compared between the two groups.Results After intervention,the stride frequency and stride speed in the transcranial direct current stimulation group were faster than those in the conventional treatment group(P<0.05).After the intervention,the balance ability score of the transcranial direct current stimulation group(34.51±3.26)was higher than that of the conventional treatment group(26.32±2.81),and the TUGT time of the transcranial direct current stimulation group was(9.46±0.71)s,shorter than the(10.27±1.03)s of the conventional treatment group(P<0.05).After the intervention,the BI and MFES scores in the transcranial direct current stimulation group(53.21±3.25,6.36±0.32)were higher than those in the conventional treatment group(46.12±3.67,5.06±0.28),P<0.05.After intervention,the MMSE and MoCA scores in the transcranial direct current stimulation group(26.75±2.05,26.59±1.96)were higher than those in the conventional treatment group(25.67±1.95,25.12±1.87),P<0.05.Conclusions Transcranial direct current stimulation combined with conventional rehabilitation training in the treatment of patients with Parkinson disease can improve the walking condition,enhance the balance ability,improve the self-care ability,and improve the cognitive function.