糖皮质激素辅助治疗儿童大叶性肺炎的效果分析

Clinical efficacy of glucocorticoid adjuvant therapy for children with lobar pneumonia

目的探讨糖皮质激素辅助治疗儿童大叶性肺炎的效果。方法抽取2020年1月至2021年12月周口市中医院收治的大叶性肺炎患儿86例,以双色球法分为对照组与观察组,每组43例。对照组采用阿奇霉素治疗,观察组采用阿奇霉素联合糖皮质激素治疗。比较两组患者的治疗效果、体征恢复时间、肺功能指标及细胞因子水平。结果观察组总有效率(95.35%,41/43)高于对照组(69.77%,30/43),体征恢复时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿肺功能、细胞因子水平比较差异未见统计学意义(P>0.05);治疗后,观察组1 s用力呼气容积、用力肺活量、呼气流量峰值均高于对照组,C反应蛋白、降钙素原、血沉水平低于对照组,差异有统计学意义(P<0.05)。结论大叶性肺炎患儿采取糖皮质激素辅助治疗,可提高疗效,改善肺功能与细胞因子水平,缩短患儿体征缓解时间,促进其更快康复。

Objective To investigate the efficacy of adjuvant glucocorticoid therapy for children with lobar pneumonia.Methods A total of 86 children with lobar pneumonia treated in Zhoukou Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were selected for the study,and they were divided into control group and observation group by the two-color ball method,with 43 cases in each group.The control group was treated with azithromycin treatment,and the observation group was treated with azithromycin combined glucocorticoid treatment.The therapeutic effect,recovery time of physical signs,pulmonary function indexes and cytokine level of the two groups were compared.Results The total effective rate of the observation group(95.35%,41/43)was higher than that of the control group(69.77%,30/43),and the recovery time of signs was shorter than that of the control group,with significant differences(P<0.05).Before treatment,there was no significant difference in lung function and cytokine level between the two groups(P>0.05);after treatment,the forced expiratory volume in 1 second,forced vital capacity and peak value of forced expiratory volume of the observation group were higher than those of the control group,while the C-reactive protein level,procalcitonin level and erythrocyte sedimentation rate were lower than those in the control group,and the differences were significant(P<0.05).Conclusions Adjuvant glucocorticoid therapy in children with lobar pneumonia can improve the curative effect,improve lung function and cytokine levels,shorten the time to relieve signs of children,and promote recovery.