鳞状上皮细胞癌抗原、E钙黏素表达水平对食管癌预后的影响

Effect of expression of squamous cell carcinoma antigen and E-cadherin on prognosis of esophageal carcinoma

目的探讨食管癌组织鳞状上皮细胞癌抗原(SCCAg)、E钙黏素(E-cadherin)不同表达情况下疾病特征、病情进展及预后的差异。方法四川大学华西空港医院收治及定期随访的194例食管癌患者,均行手术治疗并有完整的病例检查结果,比较食管癌组织及对应癌旁组织中SCCAg、E-cadherin表达水平,分析二者不同表达情况下食管癌疾病特征、病情进展的差异;随访患者术后生存情况,分析二者表达情况对食管癌患者预后预测价值。结果与癌旁组织相比,食管癌组织中SCCAg蛋白阳性表达率升高,E-cadherin蛋白阳性表达率降低(P<0.05);不同病理类型、肿瘤大小、浸润程度、病理分期的食管癌组织中SCCAg蛋白阳性表达率差异有统计学意义(P<0.05),不同肿瘤大小、浸润程度、病理分期、淋巴结转移的食管癌组织中E-cadherin蛋白阳性表达率差异有统计学意义(P<0.05);194例患者1年总生存率为91.24%(177/194),SCCAg、E-cadherin蛋白阳性组与阴性组生存率比较,差异均有统计学意义(P<0.05)。浸润程度、病理分期、淋巴结转移、SCCAg表达、E-cadherin表达是影响食管癌患者预后的危险因素(P<0.05)。结论SCCAg、E-cadherin在食管癌组织中存在差异性表达,二者均对食管癌患者预后具有一定的预测价值。

Objective To explore the differences in disease characteristics,disease progression and prognosis under different expressions of squamous cell carcinoma antigen(SCC-Ag)and E-cadherin in esophageal cancer tissues.Methods One hundred and ninety-four esophageal cancer patients who received treatment and regular follow-up in our hospital were selected.All patients underwent surgery and had complete case examination results.The expression levels of SCC-Ag and E-cadherin in esophageal cancer tissues and corresponding adjacent tissues were compared.The differences in disease characteristics and disease progression of esophageal cancer under different expressions of the two indicators were analyzed.The postoperative survival of patients was followed up.The predictive value of the expression of the two indicators in the prognosis of patients with esophageal cancer was analyzed.Results Compared with adjacent tissues,the positive expression rate of SCC-Ag protein was enhanced while the positive expression rate of E-cadherin protein was reduced in cancer tissues(P<0.05).There was a statistical significance in the positive expression rate of SCC-Ag protein in esophageal cancer tissues of patients with different pathological types,tumor sizes,infiltration degrees and pathological stages(P<0.05).There was also a statistical difference in the positive expression rate of E-cadherin protein in esophageal cancer tissues of patients with different tumor sizes,infiltration degrees,pathological stages and lymph node metastases(P<0.05).The 1-year overall survival rate of the 194 patients was 91.24%(177/194).The survival rates in the SCC-Ag positive group and the E-cadherin-positive group were significantly different from those of the negative groups(P<0.05).The invasion degree,pathological staging,lymph node metastasis,SCCAg expression and E-cadherin expression were risk factors affecting the prognosis of patients with esophageal cancer(P<0.05).Conclusions SCC-Ag and E-cadherin are differentially expressed in esophageal cancer.Both have certain predictive value in the prognosis of patients with esophageal cancer.