构建2H-吡咯-2-酮骨架的研究进展

Progress in Construction of 2H-Pyrrol-2-ones Skeleton

2H-吡咯-2-酮作为一类重要的γ-内酰胺类化合物,因其广泛存在于天然产物、药物和生物活性分子之中,同时也是药物研发和有机合成中的主要合成中间体,故备受有机合成工作者的关注.近年来,基于2H-吡咯-2-酮骨架包括1,5-二氢-2H-吡咯-2-酮的合成方法和策略取得了长足发展.通过总结不同合成方法和策略,分别对三类2H-吡咯-2-酮骨架的合成方法学的研究进展予以综述.

2H-Pyrrol-2-ones as an important class of γ-lactam compounds, widely exist in the structure of natural products,drugs and biologically active molecules, and they are also the important synthetic intermediates in drug development and organic synthesis. In recent years, the synthesis methods and strategies based on 2H-pyrrol-2-ones skeleton including 1,5-dihydro-2H-pyrrol-2-ones have made great progress. In this paper, the different synthetic methods and strategies for the construction of 2H-pyrrol-2-one skeletons are summarized.