氟环唑的制备与安全性研究

Study on the Preparation and Safety of Epoxiconazole

为加快成果转化,支撑安全生产,掌握高活性氟环唑晶体结构与构效关系,以过氧化氢和马来酸醇为氧化剂的氟环唑环氧化反应为研究对象,分析了三唑啉环氧化反应过程与安全性及二者之间的对应关系,构建了环氧化反应热失控条件,选取了最危险的情况,提出应用环氧化反应紧急急冷与超压泄爆技术,深入挖掘高活性氟环唑晶体的杀菌生物活性和应用价值,促进产品升级换代,为实现安全生产提供技术支撑。

In order to accelerate the achievement transformation,support the safety production,and grasp crystal structure of highly active flucyclozole and structure-function relationship,the epoxidation reaction of epoxiconazole synthesized with hydrogen peroxide and maleic acid as oxidants is taken as the research object;epoxidation of triazoline,its safety and the relationship between them are analyzed;thermorunaway condition of epoxidation reaction is constructed;and the most dangerous condition is selected.Then the study proposes the application of epoxidation reaction emergency quenching and overpressure relief technology,and deeply explores the bactericidal biological activity and application value of high-activity flucyclozole crystals,to promote the upgrading and updating of products,and provide technical support for safety production.