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硬膜外麻醉复合全麻对老年腹部手术患者血流动力学指标与细胞因子水平的影响 被引量:2

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摘要 目的 探讨硬膜外麻醉复合全麻对老年腹部手术患者血流动力学指标及细胞因子水平的影响,为提高老年腹部手术围术期麻醉的有效性和安全性提供依据。方法 选取新疆医科大学第六附属医院2020年1月至2022年3月收治的进行腹部手术的92例老年患者,依据随机数字表法分组研究,各46例。对照组实施全身麻醉,予以观察组患者硬膜外麻醉复合全身麻醉。对比两组患者自主呼吸恢复时间、苏醒时间、拔管时间,不同时间段[麻醉前(T_(0))、麻醉后5 min(T_(1))、麻醉后10 min(T_(2))、术后30 min(T_(3))]血流动力学指标,术前、术后24 h炎症因子、凝血功能指标。结果 观察组患者自主呼吸恢复时间、苏醒时间、拔管时间较对照组缩短;相较于T_(0)时,T_(1)~T_(3)时两组患者收缩压(SBP)、舒张压(DBP)、心率(HR)呈升高后降低趋势,且观察组均低于对照组;两组患者术后24 h白细胞介素(IL)-6、IL-1β、肿瘤坏死因子-α(TNF-α)水平较术前升高,观察组低于对照组,血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)较术前延长,但观察组短于对照组(均P<0.05)。结论 硬膜外麻醉复合全麻可减轻老年腹部手术患者机体炎症反应和凝血纤溶系统紊乱情况,稳定患者的血流动力学参数,缩短患者术后恢复的时间。
出处 《现代医学与健康研究电子杂志》 2023年第6期66-69,共4页 Modern Medicine and Health Research
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