奥施康定联合氟比洛芬酯治疗晚期胃癌骨转移的临床观察

Clinical observation of OxyContin combined with flurbiprofen ester in the treatment of advanced gastric cancer with bone metastasis

目的 分析奥施康定联合氟比洛芬酯治疗晚期胃癌骨转移患者的镇痛效果。方法 选取2020年8月至2022年3月我院收治的153例晚期胃癌骨转移患者的临床病历资料,根据患者治疗方式不同分为对照组(奥施康定)72例与观察组(奥施康定联合氟比洛芬酯治疗)81例。比较两组患者疼痛缓解效果;比较两组Mcmil Lan疼痛评分[包含疼痛分级指数(PRI)、目测类比定级法(VAS)、现有疼痛强度(PPI)];记录镇痛起效时间、爆发疼痛次数、镇痛药物用量;观察不良反应。结果 治疗后观察组患者疼痛缓解效果明显优于对照组,差异有统计学意义(P<0.05)。治疗前两组PRI、VAS、PPI评分比较均无差异(P>0.05),治疗后PRI、VAS、PPI评分均降低(P<0.05),观察组治疗后PRI、VAS、PPI评分明显低于对照组(P<0.05)。观察组镇痛起效时间快于对照组,爆发疼痛次数、镇痛药物用量均少于对照组(P<0.05)。两组不良反应总发生率差异无统计学意义(P>0.05)。结论 奥施康定联合氟比洛芬酯可降低晚期胃癌骨转移者Mcmil Lan疼痛评分,提高综合镇痛水平,安全性好。

Objective To analyze the analgesic effect of OxyContin combined with flurbiprofen axidate on patients with advanced gastric cancer with bone metastasis. Methods Clinical medical records of 153 patients with advanced gastric cancer with bone metastasis admitted to our hospital from August 2020 to March 2022 were selected and divided into control group(72 cases, oxycontin) and observation group(81 cases, oxycontin combined with flurbiprofen axidate) according to different treatment methods. The pain relief effect of the two groups was compared. Mcmil Lan pain scores(including pain grading index(PRI), visual analog scale(VAS), and existing pain intensity(PPI)) were compared between the two groups. The onset time of analgesia, the number of pain outbreaks and the amount of analgesic drugs were recorded. Observe adverse reactions. Results After treatment, the pain relief effect of the observation group was significantly better than that of the control group, and the difference was statistically significant(P<0.05). Before treatment, there were no differences in the scores of PRI, VAS and PPI between the two groups(P>0.05), and after treatment, the scores of PRI, VAS and PPI were decreased(P<0.05), and the scores of PRI, VAS and PPI in the observation group were significantly lower than those in the control group(P<0.05). The onset time of analgesia in the observation group was faster than that in the control group, the frequency of pain outbreak and the dosage of analgesic drugs were lower than those in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion OxyContin combined with flurbiprofen exate can reduce the Mcmil Lan pain score and improve the comprehensive analgesia level in patients with advanced gastric cancer with bone metastasis, with good safety.