摘要
自杀是全球重大的公共卫生问题,在全球范围内都是主要的死亡原因之一,给人类造成巨大的社会经济损失和心理伤害。抑郁症是自杀死亡的首要原因,探究抑郁症自杀的病理生理机制对于预防和减少自杀具有重要意义。抑郁症自杀与遗传、环境、社会、心理以及生物学因素关系密切。随着基因组学技术的发展,越来越多的研究者对抑郁症自杀相关基因进行探究。对近年来抑郁症自杀相关基因的研究进行综述,以期为其病理机制研究提供思路。
Suicide is a major global public health concern and is one of the leading causes of death worldwide,causing enormous socioeconomic losses and psychological damage to human beings. Major depressive disorder is the leading cause of death of suicide,and it is crucial to investigate the pathophysiological mechanisms of suicide by depression to prevent and reduce suicide. Suicide by depression is closely related to genetic,environmental,social,psychological,and biological factors. With the development of genomics technology,more and more researchers explore the genes related to suicide in depression. This study reviews recent genetic researches on suicide by depression to provide references for the study of its pathological mechanisms.
作者
储召松
王欣
和梦鑫
许秀峰
王娜
沈宗霖
CHU Zhaosong;WANG Xin;HE Mengxin;XU Xiufeng;WANG Na;SHEN Zonglin(Dept.of Psychiatry,The 1st Affiliated Hospital of Kunming Medical University,Yunnan Province Clinical Research Center for Mental Health,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2023年第3期143-148,共6页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81660237)
云南省高层次卫生计生技术人才培养项目(H-2018090)
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001(-144)]。
关键词
抑郁症
自杀
基因
Major depressive disorder
Suicide
Gene