抑郁症自杀相关基因的研究进展

Research Progress on Gene Related to Suicide in Major Depressive Disorder:A Review

自杀是全球重大的公共卫生问题,在全球范围内都是主要的死亡原因之一,给人类造成巨大的社会经济损失和心理伤害。抑郁症是自杀死亡的首要原因,探究抑郁症自杀的病理生理机制对于预防和减少自杀具有重要意义。抑郁症自杀与遗传、环境、社会、心理以及生物学因素关系密切。随着基因组学技术的发展,越来越多的研究者对抑郁症自杀相关基因进行探究。对近年来抑郁症自杀相关基因的研究进行综述,以期为其病理机制研究提供思路。

Suicide is a major global public health concern and is one of the leading causes of death worldwide,causing enormous socioeconomic losses and psychological damage to human beings. Major depressive disorder is the leading cause of death of suicide,and it is crucial to investigate the pathophysiological mechanisms of suicide by depression to prevent and reduce suicide. Suicide by depression is closely related to genetic,environmental,social,psychological,and biological factors. With the development of genomics technology,more and more researchers explore the genes related to suicide in depression. This study reviews recent genetic researches on suicide by depression to provide references for the study of its pathological mechanisms.