氟康唑联合克霉唑阴道片治疗念珠菌性阴道炎的临床效果

Comparison of clinical effects offluconazole combined with clotrimazole vaginal tablets in the treatment of candidal vaginitis

目的观察氟康唑联合克霉唑阴道片治疗念珠菌性阴道炎的临床效果。方法选取90例念珠菌性阴道炎患者,按照随机数字表法分为对照组与研究组,每组45例。对照组使用氟康唑片进行治疗,研究组在对照组基础上使用克霉唑阴道片进行治疗。比较两组的临床疗效及治疗前后炎性因子[血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平]变化情况,并观察不良反应发生情况。结果研究组治愈率为62.22%,总有效率为95.56%,均分别高于对照组的40.00%、77.78%,差异有统计学意义(P<0.05)。治疗前,两组IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、TNF-α水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。两组均未见严重不良反应发生。结论氟康唑联合克霉唑阴道片治疗念珠菌性阴道炎疗效显著,可调节患者阴道菌群失调,有效改善患者临床症状,减轻患者病情。

Objective To observe the clinical effect of fluconazole combined with clotrimazole vaginal tablets in the treatment of candidal vaginitis.Methods 90 patients with candidal vaginitis were selected and divided into control group and study group according to random number table method,with 45 cases in each group.The control group was treated withfluconazole tablets,and the study group was treated with clotrimazole vaginal tablets based on the control group.The clinical efficacy and the changes of inflammatory factors[serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before and after treatment were compared between the two groups,and the occurrence of adverse reactions was observed.Results The cure rate of the study group was 62.22%,and the total effective rate was 95.56%,which were higher than 40.00%and 77.78%of the control group,respectively,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in IL-6 and TNF-αlevels between the two groups(P>0.05).After treatment,the levels of IL-6 and TNF-αin 2 groups were lower than before,and the study group was lower than the control group,the difference was statistically significant(P<0.05).No serious adverse reactions were observed in the two groups.Conclusion Fluconazole combined with clotrimazole vaginal tablet is effective in the treatment of candida vaginitis,which can regulate the dysbiosis of vaginalflora,effectively improve the clinical symptoms and reduce the condition of patients.