奥曲肽治疗肝硬化消化道出血的疗效及对血清胆碱酯酶、氧化应激水平的影响

Effect of Octreotide on Digestive Tract Hemorrhage in Liver Cirrhosis and Its Effect on Serum Cholinesterase and Oxidative Stress

目的分析奥曲肽治疗肝硬化消化道出血的疗效。方法对我院2020年10月至2021年9月期间收治的96例肝硬化消化道出血患者进行研究,根据治疗方法的不同分为采用注射用生长抑素治疗的对照组与采用醋酸奥曲肽注射液治疗的观察组,每组48例,对比两组患者治疗前后血清CHE、SOD、MDA水平变化情况,治疗总有效率以及不良反应发生率。结果治疗后,两组患者血清CHE、SOD、MDA水平均出现不同程度的改善,但与对照组相比,观察组血清CHE、SOD水平明显更高,MDA水平明显更低,两组患者组内与组间对比均差异显著(P<0.05)。观察组患者的治疗有效率(91.67%)明显高于对照组的(75.00%),数据差异具有统计学意义(P<0.05)。两组不良反应发生率对比差异不显著(P>0.05)。结论肝硬化消化道出血疾病对患者的身体健康有着严重的生命威胁,在临床治疗上以止血为首要的治疗任务,短时间内减少出血,对促进康复具有重要的作用。对治疗肝硬化消化道出的药物种类多样化,但本文研究显示应用奥曲肽治疗的临床疗效确切,能够显著提升患者血清CHE、SOD水平,降低MDA水平,具有较高的临床应用和推广价值。

Objective To analyze the efficacy of octreotide in the treatment of gastrointestinal bleeding in cirrhosis.Methods A total of 96 patients with gastrointestinal bleeding from cirrhosis admitted to our hospital from October 2020 to September 2021 were studied.According to different treatment methods,they were divided into control group treated with somatostatin injection and observation group treated with octreotide acetate injection,48 cases in each group.The changes of serum CHE,SOD and MDA levels,the total effective rate and the incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,the serum levels of Che,SOD and MDA in the two groups were improved in different degrees,but compared with the control group,the serum levels of Che,SOD and MDA in the observation group were significantly higher and lower than those in the control group,there were significant differences between the two groups(P<0.05).The effective rate of Observation Group(91.67%)was significantly higher than that of control group(75.00%)(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The gastrointestinal bleeding disease of liver cirrhosis is a serious threat to the patients'health.Hemostasis is the primary task in clinical treatment,and bleeding can be reduced in a short time,it plays an important role in promoting rehabilitation.There are many kinds of drugs in the treatment of liver cirrhosis,but this study shows that octreotide has a definite clinical effect,it can significantly increase the serum CHE,SOD level and reduce the serum MDA level,it has high value of clinical application and popularization.