血液透析联合血液灌流对慢性肾脏病5期患者肾功能及骨代谢指标的影响

Effects of Hemodialysis Combined with Hemoperfusion on Renal Function and Bone Metabolism in Patients with Stage 5 Chronic Kidney Disease

目的探讨血液透析联合血液灌流对慢性肾脏病5期患者肾功能及骨代谢指标的影响。方法选择2020年10月至2021年10月本院收治的200例慢性肾脏病5期患者作为临床观察对象,按随机数表法分成2组,各100例。对照组行常规血液透析治疗,研究组行血液透析与血液灌流联合治疗,持续治疗3个月。统计两组近期疗效、肾功能指标及骨代谢指标、并发症发生率。结果研究组近期治疗总有效率[95.00%(95/100)]较对照组[80.00%(80/100)]更高,差异有统计学意义(P<0.05);与治疗前相比,治疗3个月后两组肾功能指标血肌酐(SCr)、尿素氮(BUN)水平均降低,且研究组低于对照组,差异有统计学意义(P<0.05);与治疗前相比,两组治疗3个月后血钙水平均有所回升,且研究组高于对照组,两组血清碱性磷酸酶(ALP)、甲状腺旁腺激素(PTH)及血磷水平均降低,且研究组低于对照组,且研究组低于对照组,差异有统计学意义(P<0.05);研究组治疗期间并发症总发生率[9.00%(9/100)]与对照组[6.00%(6/100)]对比,差异无统计学意义(P>0.05)。结论血液透析联合血液灌流治疗慢性肾脏病5期效果确切,能改善患者肾功能及骨代谢指标,且并发症少,可于临床推广。

Objective To investigate the effect of hemodialysis combined with hemoperfusion on renal function and bone metabolism in patients with CKD stage 5.Methods 200 patients with CKD stage 5 admitted to our hospital from October 2020 to October 2021 were selected as clinical observation objects,and were divided into 2 groups by random number table method,with 100 patients each.The routine hemodialysis was used in control group,hemodialysis and hemoperfusion was used in study group,treated with for 3 months.The short-term curative effect,renal function index,bone metabolism index and complication rate of the two groups were analyzed.Results the total effective rate[95.00%(95/100)]of study group was higher than[80.00%(80/100)]of control group,(P<0.05);Compared with that before treatment,the two groups’serum creatinine(SCR)and urea nitrogen(BUN)levels indecreased after 3 months of treatment,and study group’s level was lower than control group’s(P<0.05);Compared with that before treatment,the two groups’blood calcium level increased after 3 months of treatment,and study group’s level was higher than control group’s,the two groups’serum alkaline phosphatase(ALP),parathyroid hormone(PTH)and blood phosphorus level decreased,and study group’s level was lower than control group’s,(P<0.05);The total incidence of complications during treatment in the study group[9.00%(9/100)]was not significantly different from that in the control group[6.00%(6/100)](P>0.05).Conclusion hemodialysis combined with hemoperfusion can improve the renal function and bone metabolism of patients with chronic kidney disease in stage 5,with few complications,which can be popularized in clinic.Keywords:Hemodialysis;Hemoperfusion;Chronic Kidney Disease Stage 5;Renal Function;Bone Metabolism.