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SIRT1与NLRP3在子痫前期患者胎盘组织中的表达及临床意义

Expressions and clinical significances of silent information regulator 1 and nod like receptor protein 3 in placenta tissues of pregnant women with preeclampsia
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摘要 目的:探讨沉默信息调节因子1(SIRT1)和Nod样受体蛋白3(NLRP3)炎性小体在子痫前期(PE)胎盘中的表达及临床意义。方法:采用免疫组化SABC法检测SIRT1和NLRP3在胎盘石蜡切片中的表达情况,其中早发型PE 40例,晚发型PE 40例,另有正常孕妇40例作为对照组。结果:SIRT1在早发型PE组、晚发型PE组和对照组中的阳性表达率分别为12.5%、35%、92.5%,差异有统计学意义(χ^(2)=54.71,P<0.05)。NLRP3在早发型PE组、晚发型PE组和对照组中的阳性表达率分别为95%、72.5%、30%,差异有统计学意义(χ^(2)=38.75,P<0.05)。在PE胎盘组织中,SIRT1与NLRP3之间的表达水平呈负相关(r=-0.60,P<0.05)。结论:低表达的SIRT1、高表达的NLRP3可能推动了PE的发生发展。 Objective:To investigate the expressions and clinical significances of silent information regulator 1(SIRT1)and nod like receptor protein 3(NLRP3)in placenta tissues of pregnant women withpreeclampsia(PE).Methods:The expressions of SIRT1 and NLRP3 in paraffin sections of placenta tissues of 80 pregnant women with PE were detected by immunohistochemical method.40 women with early-onset PE were in group A,and 40 women with late-onset PE were in group B.Another 40 normal pregnant women were selected in group C.Results:The positive rates of the SIRT1 expression in placenta tissues of the women in group A,group B,and group C were 12.5%,35%,and 92.5%,respectively,and which had significantly different among the three groups(χ^(2)=54.71,P<0.05).The positive rates of the NLRP3 expression in placenta tissues of the women in group A,group B,and group C were 95%,72.5%,and 30%,respectively,and which had significantly different among the three groups(χ^(2)=38.75,P<0.05).The expression level of SirT1 in placental tissues of the women with PE was negatively correlated with their NLRP3 level in placental tissues(r=-0.60,P<0.05).Conclusion:The low expression of SIRT1 and the high expression of NLRP3 in placenta tissues of the women may promote the occurrence and development of their PE,and both SIRT1 and NLRP3 may involve in the occurrence and development of PE.
作者 姜桐 薛秀珍 JIANG Tong;XUE Xiuzhen(The First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Luoyang,Henan Province,471003)
出处 《中国计划生育学杂志》 2023年第3期658-661,740,共5页 Chinese Journal of Family Planning
基金 河南省医学科技攻关指导性计划项目(201504026)。
关键词 子痫前期 胎盘 沉默信息调节因子1(SIRT1) Nod样受体蛋白3(NLRP3) Preeclampsia Placenta Silent information regulator 1 Nod like receptor protein 3
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