揿针联合穴位贴敷治疗脑梗死后顽固性呃逆的疗效观察及对血清sICAM-1、GMP-140水平的影响

Observation of the therapeutic effect of thumbtack needling combined with acupoint application in the treatment of intractable hiccup after cerebral infarction and its effect on serum sICAM-1 and GMP-140 levels

目的观察揿针联合穴位贴敷对脑梗死后顽固性呃逆的临床疗效及对血清可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)、血小板膜蛋白-140(platelet membrane protein-140,GMP-140)水平的影响。方法将130例脑梗死后顽固性呃逆患者随机分为观察组和对照组,每组65例。两组均予脑梗死的常规治疗,对照组在脑梗死的常规治疗的基础上采用顽固性呃逆的常规治疗,观察组在对照组治疗基础上采用揿针联合穴位贴敷治疗。观察两组治疗前后顽固性呃逆发作频率、发作持续时间、呃逆症状评分、血清sICAM-1和GMP-140水平及呃逆生活质量评分,并比较两组临床疗效及不良反应发生率。结果观察组总有效率为90.8%,高于对照组的76.9%(P<0.05)。治疗后,两组顽固性呃逆发作频率、发作持续时间、呃逆症状评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清sICAM-1、GMP-140水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组呃逆生活质量评分升高,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在脑梗死和顽固性呃逆的常规治疗基础上,揿针联合穴位贴敷治疗脑梗死后顽固性呃逆效果显著,可降低呃逆发作频率、持续时间、症状评分及血清sICAM-1和GMP-140水平,改善患者生活质量。

Objective To observe the therapeutic effect of thumbtack needling combined with acupoint application on intractable hiccup after cerebral infarction and its effect on soluble intercellular adhesion molecule-1(sICAM-1)and platelet membrane protein-140(GMP-140).Method A total of 130 patients with intractable hiccup after cerebral infarction were randomly divided into an observation group and a control group,with 65 cases in each group.Both groups were given the conventional treatment of cerebral infarction.The control group was given the conventional treatment of intractable hiccup in addition to the conventional treatment of cerebral infarction.The observation group was treated with thumbtack needling and acupoint application in addition to the treatment used in the control group.The frequency of intractable hiccup,duration of hiccup,hiccup symptom score,serum sICAM-1 and GMP-140 levels and hiccup life quality score were observed in the two groups before and after treatment,and the clinical efficacy and incidence of adverse reactions were compared between the two groups.Result The total effective rate of the observation group was 90.8%,which was higher than 76.9%of the control group(P<0.05).After treatment,the frequency of intractable hiccup,duration of hiccup and hiccup symptom score in the two groups were all reduced,and those in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of serum sICAM-1 and GMP-140 in the two groups were decreased,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the hiccup life quality score in the two groups was increased,and it was higher in the observation group than in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In addition to the basis of the conventional treatment of cerebral infarction and intractable hiccup,thumbtack needling combined with acupoint application has a significant effect on intractable hiccup after cerebral infarction,which can reduce the hiccup frequency,hiccup duration,hiccup symptom score,serum sICAM-1 and GMP-140 levels,and improve the quality of life of patients.