毫火针联合穴位埋线治疗白癜风的疗效观察及对血清IL-2、IL-6水平的影响

Efficacy observation of filiform fire needling combined with acupoint thread embedding for vitiligo and its effects on serum IL-2 and IL-6 levels

目的观察毫火针联合穴位埋线治疗白癜风的临床疗效及对血清白介素-2(interleukin-2,IL-2)和白介素-6(interleukin-6,IL-6)水平的影响。方法将80例白癜风稳定期患者随机分为对照组和观察组,每组40例。对照组予以西医常规治疗(卤米松软膏和卡泊三醇软膏外擦及窄谱光紫外线治疗仪照射治疗),观察组在对照组治疗的基础上采用毫火针联合穴位埋线治疗。观察两组治疗前后皮损面积、血清IL-2和IL-6水平,并比较两组临床疗效及不良反应发生率。结果观察组的总有效率为92.5%,高于对照组的70.0%,差异有统计学意义(P<0.05)。治疗后,两组皮损面积均减少,且观察组皮损面积小于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清IL-2水平升高,血清IL-6水平降低,差异有统计学意义(P<0.05);观察组血清IL-2水平高于对照组,血清IL-6水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论在西医常规治疗的基础上,毫火针联合穴位埋线治疗白癜风可明显减小皮损面积,升高血清IL-2水平,降低血清IL-6水平,安全性高。

Objective To observe the clinical efficacy of filiform fire needling combined with acupoint thread embedding in treating vitiligo and its effects on the levels of serum interleukin-2(IL-2)and interleukin-6(IL-6).Method Eighty patients with stable vitiligo were randomized into a control group and an observation group,with 40 cases in each group.The control group received conventional Western medicine treatment(external use of Halometasone cream and Calcipotriol ointment plus narrow-spectrum ultraviolet radiation),and the observation group received additional filiform fire needling combined with acupoint thread embedding.The skin lesion size and levels of serum IL-2 and IL-6 were observed before and after treatment in the two groups.Clinical efficacy and adverse reaction rate were compared.Result The total effective rate was 92.5%in the observation group,higher than 70.0%in the control group,and the difference was statistically significant(P<0.05).After treatment,the skin lesion size was reduced in both groups and was smaller in the observation group than in the control group,presenting statistical significance(P<0.05).The serum IL-2 level increased,and the serum IL-6 level decreased in both groups after treatment,and the differences were statistically significant(P<0.05);the serum IL-2 level was higher and the serum IL-6 level was lower in the observation group than in the control group,showing statistical significance(P<0.05).There was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion Based on the conventional Western medicine treatment,filiform fire needling plus acupoint thread embedding can notably reduce skin lesion size,up-regulate the serum IL-2 level,and down-regulate the serum IL-6 level in treating vitiligo,with a high safety rating.