慢性胰腺炎与肠道菌群的研究进展

Progress on chronic pancreatitis and gut microbiota

肠道菌群在消化系统疾病中发挥着重要作用,日益受到人们的重视。慢性胰腺炎是临床较常见的消化系统疾病,其致病机制未完全明确。肠道微生态失调与多种胰腺疾病相关;同样慢性胰腺炎的发病与肠道菌群失衡存在相关性,肠道微生态平衡被打破,出现不同程度的肠道菌群失调和细菌移位,影响慢性胰腺炎的发生发展。该文分析肠道菌群在慢性胰腺炎中的变化以及可能的机制,为探讨肠道菌群在慢性胰腺炎诊治中的临床价值提供参考。

Gut microbiota plays an important role in digestive system diseases and has been paid more and more attention.Chronic pancreatitis is a common clinical disease of digestive system,its pathogenesis is not completely clear.Gastrointestinal microflora dysbiosis is associated with many pancreatic diseases.Similarly,the occurrence of chronic pancreatitis is related to the gut microbiota dysbiosis,and the intestinal microecological balance is broken,resulting in varying degrees of gastrointestinal microflora dysbiosis and bacterial translocation,which affects the occurrence and development of chronic pancreatitis.This review analyzes the changes of gut microbiota in chronic pancreatitis and the possible pathogenesis,so as to provide a reference for discussing the clinical value of gut microbiota in the diagnosis and treatment of chronic pancreatitis.