青少年抑郁障碍与基因多态性的研究进展

Recent research on the association between depressive disorder and gene polymorphisms in adolescents

生物遗传学在青少年抑郁障碍发病过程中发挥重要作用,基因多态性研究更新了对青少年抑郁障碍的理解。然而,在基因-环境相互作用及青少年发育年龄因素的影响下,基因多态性对青少年抑郁障碍的影响错综复杂。研究并阐明抑郁相关基因多态性与青少年抑郁障碍的关系有助于抑郁障碍发病机制的研究,为青少年时期抑郁障碍的预防和治疗提供新的线索。该文围绕青少年抑郁障碍的相关基因多态性进行了综述。

Biogenetics plays an important role in the pathogenesis of depressive disorder in adolescents.Various genetic polymorphism studies have updated the understanding of adolescent depressive disorder.However,due to the influence of gene-environment interaction and age of puberty,the influence of gene polymorphisms on adolescent depressive disorder is complicated to clarify.Investigating and clarifying the relationship between gene polymorphisms and adolescent depressive disorder will promote the research on the pathogenesis of this disorder and provide a reference for the prevention and treatment of this disorder.This article reviews the genetic polymorphisms related to adolescent depressive disorder.