灼灸联合米非司酮治疗产后胎盘残留效果及对产妇氧化应激反应的影响

The Effect of Burning Moxibustion Combined with Mifepristone in the Treatment of Postpartum Placenta Residue and Its Effect on Maternal Oxidative Stress

目的:探究灼灸联合米非司酮治疗产后胎盘残留效果及对产妇氧化应激反应的影响,为相关疾病的临床治疗提供参考。方法:选取2020年7月—2021年12月上海市嘉定区安亭医院收治的产后胎盘残留患者90例,根据接受的治疗方式将其分为西药组、灼灸组与联合组,每组各纳入患者30例。西药组:仅给予患者米非司酮治疗;灼灸组:患者仅接受中医灼灸治疗;联合组:患者同时接受米非司酮与灼灸治疗。结果:治疗后,西药组患者胎盘残留面积及β-HCG水平均明显高于灼灸组和联合组患者,灼灸组患者胎盘残留面积及β-HCG水平均明显高于联合组患者;西药组患者恶露持续时间、子宫体积明显高于灼灸组和联合组患者,子宫下降速度明显低于灼灸组和联合组患者;灼灸组患者恶露持续时间、子宫体积明显高于联合组患者,子宫下降速度明显低于联合组患者;西药组患者超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平均明显低于灼灸组和联合组患者,活性氧(ROS)水平明显高于灼灸组和联合组患者;灼灸组患者SOD、CAT水平均明显低于联合组患者,ROS水平明显高于联合组患者。结论:灼灸联合米非司酮治疗产后胎盘残留相较于单独使用米非司酮或灼灸的治疗效果更好,且治疗后患者子宫恢复更快,可减轻机体的应激反应。

OBJECTIVE To explore the effect of burning moxibustion combined with mifepristone in the treatment of postpartum placental residual and its effect on maternal oxidative stress.METHODS A total of 90 patients with postpartum placental residues who were admitted to our hospital from July 2020 to December 2021 were selected as the research subjects,and they were divided into a western medicine group,a burning moxibustion group and a combination group according to the treatment methods they received,with 30 cases in each group.The western medicine group was only given mifepristone,the burning moxibustion group only received traditional Chinese medicine burning moxibustion,and the combination group received traditional Chinese medicine burning moxibustion on the basis of mifepristone.RESULTS The residual area of placenta and the level ofβ-HCG in the western medicine group were significantly higher than those in the burning moxibustion group and the combination group.The residual area of placenta and the level ofβ-HCG in the burning moxibustion group were significantly higher than those in the combination group.The lochia duration and uterine volume of the western medicine group were significantly higher than those of the burning moxibustion group and the combined group,and the uterine descent speed was significantly lower than that of the burning moxibustion group and the combined group.The lochia duration and uterine volume of the burning moxibustion group were significantly higher than those of the combined group,and the uterine descent speed was significantly lower than that of the combined group.The levels of SOD and CAT in the western medicine group were significantly lower than those in the moxibustion group and the combined group,and ROS was significantly higher than that in the moxibustion group and the combined group.The levels of SOD and CAT in the moxibustion group were significantly lower than those in the combined group,and ROS was significantly higher than that in the combined group.CONCLUSION Burning moxibustion combined with mifepristone in the treatment of postpartum residual placenta is more effective than using mifepristone alone or receiving burning moxibustion,and the uterus recovers faster after treatment,which can reduce the body’s stress response.