CMTM2基因对于雄性动物生殖的影响机理研究进展

Advances in the Regulation Mechanism of CMTM2 Gene on Male Reproductive of Animals

CMTM2基因在雄性动物的睾丸组织中高度表达,其可以通过一系列的分子机制来影响繁殖性能,如通过调节雄激素受体在睾丸组织中的表达来影响精子发生;CMTM2的异常表达会引起睾酮分泌异常,导致睾丸萎缩,最终导致雄性不育。为此,本文首先介绍了CMTM2基因及其表达特征,综述了该基因对雄性动物生殖系统的影响以及它与雄性动物不育之间的关系,以期为动物的品种选育及繁殖率的提高提供新思路。

CMTM2 gene is highly expressed in testicular tissue of male animals, and it can affect reproductive performance through a series of molecular mechanisms, such as regulating the expression of androgen receptor in testicular tissue to affect spermatogenesis. Abnormal expression of CMTM2 can cause abnormal testosterone secretion, resulting in testicular atrophy,and ultimately male infertility. In this paper, we first introduced the CMTM2 gene and its expression characteristics, and reviewed the effect of CMTM2 gene on the reproductive system of male animals and its relationship with male sterility, in order to provide new ideas for breeding and improving the reproductive rate of animals.